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Double-stranded flanking ends affect the folding kinetics and conformational equilibrium of G-quadruplexes forming sequences within the promoter of KIT oncogene

G-quadruplexes embedded within promoters play a crucial role in regulating the gene expression. KIT is a widely studied oncogene, whose promoter contains three G-quadruplex forming sequences, c-kit1, c-kit2 and c-kit*. For these sequences available studies cover ensemble and single-molecule analyses...

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Detalles Bibliográficos
Autores principales:	Vesco, Guglielmo, Lamperti, Marco, Salerno, Domenico, Marrano, Claudia Adriana, Cassina, Valeria, Rigo, Riccardo, Buglione, Enrico, Bondani, Maria, Nicoletto, Giulia, Mantegazza, Francesco, Sissi, Claudia, Nardo, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464035/ https://www.ncbi.nlm.nih.gov/pubmed/34478543 http://dx.doi.org/10.1093/nar/gkab674

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