Transcriptional silencing of fetal hemoglobin expression by NonO

Human fetal globin (γ-globin) genes are developmentally silenced after birth, and reactivation of γ-globin expression in adulthood ameliorates symptoms of hemoglobin disorders, such as sickle cell disease (SCD) and β-thalassemia. However, the mechanisms by which γ-globin expression is precisely regu...

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Detalles Bibliográficos
Autores principales: Li, Xinyu, Chen, Mengxia, Liu, Biru, Lu, Peifen, Lv, Xiang, Zhao, Xiang, Cui, Shuaiying, Xu, Peipei, Nakamura, Yukio, Kurita, Ryo, Chen, Bing, Huang, David C S, Liu, De-Pei, Liu, Ming, Zhao, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464040/
https://www.ncbi.nlm.nih.gov/pubmed/34379783
http://dx.doi.org/10.1093/nar/gkab671

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