Charcot–Marie–Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response

Toxic gain-of-function mutations in aminoacyl-tRNA synthetases cause a degeneration of peripheral motor and sensory axons, known as Charcot–Marie–Tooth (CMT) disease. While these mutations do not disrupt overall aminoacylation activity, they interfere with translation via an unknown mechanism. Here,...

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Detalles Bibliográficos
Autores principales: Mendonsa, Samantha, von Kuegelgen, Nicolai, Bujanic, Lucija, Chekulaeva, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464049/
https://www.ncbi.nlm.nih.gov/pubmed/34403468
http://dx.doi.org/10.1093/nar/gkab730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464049/
https://www.ncbi.nlm.nih.gov/pubmed/34403468
http://dx.doi.org/10.1093/nar/gkab730

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