Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells

Telomere maintenance is essential to preserve genomic stability and involves telomere-specific proteins, DNA replication and repair proteins. Lamins are key components of the nuclear envelope and play numerous roles, including maintenance of the nuclear integrity, regulation of transcription, and DN...

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Detalles Bibliográficos
Autores principales: Pennarun, Gaëlle, Picotto, Julien, Etourneaud, Laure, Redavid, Anna-Rita, Certain, Anaïs, Gauthier, Laurent R, Fontanilla-Ramirez, Paula, Busso, Didier, Chabance-Okumura, Caroline, Thézé, Benoît, Boussin, François D, Bertrand, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464066/
https://www.ncbi.nlm.nih.gov/pubmed/34469544
http://dx.doi.org/10.1093/nar/gkab761

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