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Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters
BACKGROUND: Newly, chemo‐preventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural based constituents. Malignancy urges to augment effectual chemo‐preventive agents that are look forward to suppress the tumours which may be st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464247/ https://www.ncbi.nlm.nih.gov/pubmed/33949808 http://dx.doi.org/10.1002/vms3.500 |
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author | Liu, Min Wen, Chengquan Pan, Shengqi |
author_facet | Liu, Min Wen, Chengquan Pan, Shengqi |
author_sort | Liu, Min |
collection | PubMed |
description | BACKGROUND: Newly, chemo‐preventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural based constituents. Malignancy urges to augment effectual chemo‐preventive agents that are look forward to suppress the tumours which may be stimulated by chewing and smoking of tobacco and over alcohol consumption related with the high prevalence of human oral cancer (OC) patients. METHODS: In the present research, we examined to assess antioxidants, lipid peroxidation (LPO) and detoxification enzymes levels of anticancer activity of mangiferin on 0.5% 7.12‐dimethylbenz[a]anthracene (DMBA) provoked hamster cheek pouch carcinoma (HCPC). OC on hamster buccal pouch (HBP) was incited by DMBA treatment for thrice per week for over 14 weeks. RESULTS: 100% well defined OC establishment with body weight (bw), tumour burden (TB), antioxidant, LPO and liver marker enzymes and also histological changes were observed on DMBA‐challenged buccal pouch carcinoma (BPC) in hamsters. Orally treated mangiferin at an effective dosage of 50 mg/kg bw, to DMBA painted hamsters were significantly averted the body weight, succession of tumour, the biochemical as well as histopathological changes. CONCLUSION: Findings of this work clearly suggest that the anti‐carcinoma effect of mangiferin possesses the modulator effects on potent antioxidant, anti‐LPO and detoxification agents to expel the metabolites of malignant cells, on DMBA‐provoked BPC in hamsters. |
format | Online Article Text |
id | pubmed-8464247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-84642472021-10-01 Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters Liu, Min Wen, Chengquan Pan, Shengqi Vet Med Sci Original Articles BACKGROUND: Newly, chemo‐preventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural based constituents. Malignancy urges to augment effectual chemo‐preventive agents that are look forward to suppress the tumours which may be stimulated by chewing and smoking of tobacco and over alcohol consumption related with the high prevalence of human oral cancer (OC) patients. METHODS: In the present research, we examined to assess antioxidants, lipid peroxidation (LPO) and detoxification enzymes levels of anticancer activity of mangiferin on 0.5% 7.12‐dimethylbenz[a]anthracene (DMBA) provoked hamster cheek pouch carcinoma (HCPC). OC on hamster buccal pouch (HBP) was incited by DMBA treatment for thrice per week for over 14 weeks. RESULTS: 100% well defined OC establishment with body weight (bw), tumour burden (TB), antioxidant, LPO and liver marker enzymes and also histological changes were observed on DMBA‐challenged buccal pouch carcinoma (BPC) in hamsters. Orally treated mangiferin at an effective dosage of 50 mg/kg bw, to DMBA painted hamsters were significantly averted the body weight, succession of tumour, the biochemical as well as histopathological changes. CONCLUSION: Findings of this work clearly suggest that the anti‐carcinoma effect of mangiferin possesses the modulator effects on potent antioxidant, anti‐LPO and detoxification agents to expel the metabolites of malignant cells, on DMBA‐provoked BPC in hamsters. John Wiley and Sons Inc. 2021-05-05 /pmc/articles/PMC8464247/ /pubmed/33949808 http://dx.doi.org/10.1002/vms3.500 Text en © 2021 The Authors Veterinary Medicine and Science Published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Liu, Min Wen, Chengquan Pan, Shengqi Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title | Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title_full | Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title_fullStr | Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title_full_unstemmed | Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title_short | Modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
title_sort | modulator effect of mangiferin on biochemical characterization in 7,12‐dimethylbenz[a]anthracene induced oral cancer in experimental hamsters |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464247/ https://www.ncbi.nlm.nih.gov/pubmed/33949808 http://dx.doi.org/10.1002/vms3.500 |
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