Cargando…

Farnesylthiosalicylic Acid-Loaded Albumin Nanoparticle Alleviates Renal Fibrosis by Inhibiting Ras/Raf1/p38 Signaling Pathway

BACKGROUND: Renal fibrosis is the common pathway in chronic kidney diseases progression to end-stage renal disease, but to date, no clinical drug for its treatment is approved. It has been demonstrated that the inhibitor of proto-oncogene Ras, farnesylthiosalicylic acid (FTS), shows therapeutic pote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Hui, Liu, Qinhui, Zhang, Ting, Zhang, Jinhang, Zhou, Jian, Jing, Xiandan, Tang, Qin, Huang, Cuiyuan, Zhang, Zijing, Zhao, Yingnan, Zhang, Guorong, Yan, Jiamin, Xia, Yan, Xu, Ying, Li, Jiahui, Li, Yanping, He, Jinhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464329/ https://www.ncbi.nlm.nih.gov/pubmed/34584410 http://dx.doi.org/10.2147/IJN.S318124

Ejemplares similares

Canagliflozin Facilitates Reverse Cholesterol Transport Through Activation of AMPK/ABC Transporter Pathway
por: Zhao, Yingnan, et al.
Publicado: (2021)

MANF in POMC Neurons Promotes Brown Adipose Tissue Thermogenesis and Protects Against Diet-Induced Obesity
por: Tang, Qin, et al.
Publicado: (2022)

Sirt6 Alleviated Liver Fibrosis by Deacetylating Conserved Lysine 54 on Smad2 in Hepatic Stellate Cells
por: Zhang, Jinhang, et al.
Publicado: (2020)

Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway
por: Wu, Tong, et al.
Publicado: (2021)

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway
por: Yang, Xuping, et al.
Publicado: (2020)

Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling
por: Tang, Qin, et al.
Publicado: (2020)

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury
por: Pu, Shiyun, et al.
Publicado: (2019)

Novel Therapeutic Targets in Liver Fibrosis
por: Zhang, Jinhang, et al.
Publicado: (2021)

Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease
por: Wang, Xiang, et al.
Publicado: (2019)

Farnesylthiosalicylic acid-derivatized PEI-based nanocomplex for improved tumor vaccination
por: Chen, Yuang, et al.
Publicado: (2021)

Farnesylthiosalicylic acid sensitizes hepatocarcinoma cells to artemisinin derivatives
por: Wu, Liping, et al.
Publicado: (2017)

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis
por: Pu, Shiyun, et al.
Publicado: (2021)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis
por: Li, Yanping, et al.
Publicado: (2019)

The Ras Antagonist, Farnesylthiosalicylic Acid (FTS), Decreases Fibrosis and Improves Muscle Strength in dy(2J)/dy(2J) Mouse Model of Muscular Dystrophy
por: Nevo, Yoram, et al.
Publicado: (2011)

PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy
por: Li, Yanping, et al.
Publicado: (2019)

Ras and Raf pathways in epidermis development and carcinogenesis
por: Kern, F, et al.
Publicado: (2011)

Ras and Raf pathways in epidermis development and carcinogenesis
por: Kern, F, et al.
Publicado: (2011)

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
por: Tran, Timothy H., et al.
Publicado: (2021)

Molecular recognition of RAS/RAF complex at the membrane: Role of RAF cysteine-rich domain
por: Travers, Timothy, et al.
Publicado: (2018)

RDM1 promotes neuroblastoma growth through the RAS–Raf–MEK–ERK pathway
por: Xie, Guojin, et al.
Publicado: (2019)

SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway
por: Zhang, Jinhang, et al.
Publicado: (2018)

Crystal Structure Reveals the Full Ras–Raf Interface and Advances Mechanistic Understanding of Raf Activation
por: Cookis, Trinity, et al.
Publicado: (2021)

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
por: Ilter, Metehan, et al.
Publicado: (2022)

An engineered protein antagonist of K-Ras/B-Raf interaction
por: Kauke, Monique J., et al.
Publicado: (2017)

Does Ras Activate Raf and PI3K Allosterically?
por: Nussinov, Ruth, et al.
Publicado: (2019)

Cryo-EM structure of a RAS/RAF recruitment complex
por: Park, Eunyoung, et al.
Publicado: (2023)

Immune responses in diabetic nephropathy: Pathogenic mechanisms and therapeutic target
por: Chen, Jiahao, et al.
Publicado: (2022)

Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway
por: Rao, Qing, et al.
Publicado: (2022)

The Role of Sirt6 in Obesity and Diabetes
por: Kuang, Jiangying, et al.
Publicado: (2018)

Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma
por: Wong, Kwan Yeung, et al.
Publicado: (2018)

RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors
por: Yuan, Xi, et al.
Publicado: (2020)

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis
por: Fritsche-Guenther, Raphaela, et al.
Publicado: (2016)

Role of autophagy in K-RAS- and B-RAF-driven lung cancers
por: White, Eileen
Publicado: (2014)

T cell leukemia control via Ras-Raf pathway inhibition with peptides
por: Marin, G, et al.
Publicado: (2017)

Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
por: Gonzalez-Hormazabal, Patricio, et al.
Publicado: (2018)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
por: Degirmenci, Ufuk, et al.
Publicado: (2020)

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling
por: Nolan, Aoife A., et al.
Publicado: (2021)

Targeting Cadherin-17 Inactivates Ras/Raf/MEK/ERK Signaling and Inhibits Cell Proliferation in Gastric Cancer
por: Lin, Zhaohu, et al.
Publicado: (2014)

Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway
por: Chen, Xiang-Yan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gue7t7dtg7p031mhnoe7h6deos