lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

BACKGROUND: Long non-coding RNAs (lncRNAs) have been implicated in initiation and development of numerous cancers. In the present study, we explored the role of lncRNAs AC007207.2 in osteosarcoma (OS). METHODS: Gene expression data of OS tissues was downloaded from the TARGET database. All the exper...

Descripción completa

Detalles Bibliográficos
Autores principales: Dang, Youting, Zhou, Yunping, Ou, Xuehai, Wang, Qiang, Wei, Dengke, Xie, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464591/
https://www.ncbi.nlm.nih.gov/pubmed/34584454
http://dx.doi.org/10.2147/CMAR.S318975
_version_ 1784572661084454912
author Dang, Youting
Zhou, Yunping
Ou, Xuehai
Wang, Qiang
Wei, Dengke
Xie, Fei
author_facet Dang, Youting
Zhou, Yunping
Ou, Xuehai
Wang, Qiang
Wei, Dengke
Xie, Fei
author_sort Dang, Youting
collection PubMed
description BACKGROUND: Long non-coding RNAs (lncRNAs) have been implicated in initiation and development of numerous cancers. In the present study, we explored the role of lncRNAs AC007207.2 in osteosarcoma (OS). METHODS: Gene expression data of OS tissues was downloaded from the TARGET database. All the experiments were repeated at least three times. Data were analyzed using Perl, R, SPSS v12.0 and GraphPad Prism 8 software. RESULTS: We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS. Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells. CONCLUSION: lncRNA AC007207.2 promotes progression of OS by upregulating SIRT7 expression through miR-1306-5p sponging. Thus, lncRNA AC007207.2/miR-1306-5p/SIRT7 axis is a promising therapeutic target for OS treatment.
format Online
Article
Text
id pubmed-8464591
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-84645912021-09-27 lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis Dang, Youting Zhou, Yunping Ou, Xuehai Wang, Qiang Wei, Dengke Xie, Fei Cancer Manag Res Original Research BACKGROUND: Long non-coding RNAs (lncRNAs) have been implicated in initiation and development of numerous cancers. In the present study, we explored the role of lncRNAs AC007207.2 in osteosarcoma (OS). METHODS: Gene expression data of OS tissues was downloaded from the TARGET database. All the experiments were repeated at least three times. Data were analyzed using Perl, R, SPSS v12.0 and GraphPad Prism 8 software. RESULTS: We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS. Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells. CONCLUSION: lncRNA AC007207.2 promotes progression of OS by upregulating SIRT7 expression through miR-1306-5p sponging. Thus, lncRNA AC007207.2/miR-1306-5p/SIRT7 axis is a promising therapeutic target for OS treatment. Dove 2021-09-21 /pmc/articles/PMC8464591/ /pubmed/34584454 http://dx.doi.org/10.2147/CMAR.S318975 Text en © 2021 Dang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Dang, Youting
Zhou, Yunping
Ou, Xuehai
Wang, Qiang
Wei, Dengke
Xie, Fei
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title_full lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title_fullStr lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title_full_unstemmed lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title_short lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
title_sort lncrna ac007207.2 promotes malignant properties of osteosarcoma via the mir-1306-5p/sirt7 axis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464591/
https://www.ncbi.nlm.nih.gov/pubmed/34584454
http://dx.doi.org/10.2147/CMAR.S318975
work_keys_str_mv AT dangyouting lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis
AT zhouyunping lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis
AT ouxuehai lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis
AT wangqiang lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis
AT weidengke lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis
AT xiefei lncrnaac0072072promotesmalignantpropertiesofosteosarcomaviathemir13065psirt7axis

Ejemplares similares