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A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy

BACKGROUND: Intra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress to a chronic state over time. We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders. RESULTS: Sixty boys with hem...

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Autores principales: Zhang, Ningning, Yang, Sheng, Zwagemaker, Anne-Fleur, Huo, Aihua, Li, Ying-Jia, Zhou, Fang, Hilliard, Pamela, Squire, Sandra, Bouskill, Vanessa, Mohanta, Arun, Zhou, Alex, Jarrin, Jose, Wu, Runhui, Sun, Jing, Luke, Brian, Moineddin, Rahim, Blanchette, Victor S., Peng, Yun, Doria , Andrea S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464640/
https://www.ncbi.nlm.nih.gov/pubmed/34564747
http://dx.doi.org/10.1186/s13244-021-01043-0
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author Zhang, Ningning
Yang, Sheng
Zwagemaker, Anne-Fleur
Huo, Aihua
Li, Ying-Jia
Zhou, Fang
Hilliard, Pamela
Squire, Sandra
Bouskill, Vanessa
Mohanta, Arun
Zhou, Alex
Jarrin, Jose
Wu, Runhui
Sun, Jing
Luke, Brian
Moineddin, Rahim
Blanchette, Victor S.
Peng, Yun
Doria , Andrea S.
author_facet Zhang, Ningning
Yang, Sheng
Zwagemaker, Anne-Fleur
Huo, Aihua
Li, Ying-Jia
Zhou, Fang
Hilliard, Pamela
Squire, Sandra
Bouskill, Vanessa
Mohanta, Arun
Zhou, Alex
Jarrin, Jose
Wu, Runhui
Sun, Jing
Luke, Brian
Moineddin, Rahim
Blanchette, Victor S.
Peng, Yun
Doria , Andrea S.
author_sort Zhang, Ningning
collection PubMed
description BACKGROUND: Intra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress to a chronic state over time. We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders. RESULTS: Sixty boys with hemophilia and 3 boys with type 3 von Willebrand disease aged 5 to 18 years (median 12.3 years) were imaged by gray-scale and color Doppler ultrasound (US) in three centers (Beijing, China [n = 22], Guangzhou, China [n = 12] and Toronto, Canada [n = 29])) in this observational study. Images were independently reviewed by two radiologists blinded to clinical data using a subjective semi-quantitative scoring system and objective measurements of synovial thickness and vascularity. Inter-reader reliability for using subjective versus objective color Doppler US methods for assessing synovial vascularity was excellent for the subjective method and moderate/lower range of substantial for the objective method. Agreement between degree of vascularity on color Doppler and extent of synovial hypertrophy on gray-scale US was overall poor for Canada data and moderate for China data. Correlations between degree of vascularity on color Doppler and synovial hypertrophy on gray-scale US, and clinical constructs (total and itemized HJHS scores and total Pettersson X-ray scores) for assessment of blood-induced arthropathy were all poor. CONCLUSION: Color Doppler US is a valuable scoring method for evaluating reactive synovitis in joints of subjects with inherited bleeding disorders and holds potential for assessing post-bleed reactive synovitis once further information on its association with timing of the joint bleed becomes available in the literature. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-021-01043-0.
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spelling pubmed-84646402021-10-08 A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy Zhang, Ningning Yang, Sheng Zwagemaker, Anne-Fleur Huo, Aihua Li, Ying-Jia Zhou, Fang Hilliard, Pamela Squire, Sandra Bouskill, Vanessa Mohanta, Arun Zhou, Alex Jarrin, Jose Wu, Runhui Sun, Jing Luke, Brian Moineddin, Rahim Blanchette, Victor S. Peng, Yun Doria , Andrea S. Insights Imaging Original Article BACKGROUND: Intra-articular bleeds in patients with inherited bleeding disorders lead to active synovitis which may progress to a chronic state over time. We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders. RESULTS: Sixty boys with hemophilia and 3 boys with type 3 von Willebrand disease aged 5 to 18 years (median 12.3 years) were imaged by gray-scale and color Doppler ultrasound (US) in three centers (Beijing, China [n = 22], Guangzhou, China [n = 12] and Toronto, Canada [n = 29])) in this observational study. Images were independently reviewed by two radiologists blinded to clinical data using a subjective semi-quantitative scoring system and objective measurements of synovial thickness and vascularity. Inter-reader reliability for using subjective versus objective color Doppler US methods for assessing synovial vascularity was excellent for the subjective method and moderate/lower range of substantial for the objective method. Agreement between degree of vascularity on color Doppler and extent of synovial hypertrophy on gray-scale US was overall poor for Canada data and moderate for China data. Correlations between degree of vascularity on color Doppler and synovial hypertrophy on gray-scale US, and clinical constructs (total and itemized HJHS scores and total Pettersson X-ray scores) for assessment of blood-induced arthropathy were all poor. CONCLUSION: Color Doppler US is a valuable scoring method for evaluating reactive synovitis in joints of subjects with inherited bleeding disorders and holds potential for assessing post-bleed reactive synovitis once further information on its association with timing of the joint bleed becomes available in the literature. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13244-021-01043-0. Springer International Publishing 2021-09-25 /pmc/articles/PMC8464640/ /pubmed/34564747 http://dx.doi.org/10.1186/s13244-021-01043-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Zhang, Ningning
Yang, Sheng
Zwagemaker, Anne-Fleur
Huo, Aihua
Li, Ying-Jia
Zhou, Fang
Hilliard, Pamela
Squire, Sandra
Bouskill, Vanessa
Mohanta, Arun
Zhou, Alex
Jarrin, Jose
Wu, Runhui
Sun, Jing
Luke, Brian
Moineddin, Rahim
Blanchette, Victor S.
Peng, Yun
Doria , Andrea S.
A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title_full A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title_fullStr A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title_full_unstemmed A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title_short A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
title_sort semiquantitative color doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464640/
https://www.ncbi.nlm.nih.gov/pubmed/34564747
http://dx.doi.org/10.1186/s13244-021-01043-0
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