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Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases. However, the mechanisms that regulate CMA are not fully understood. Here, using unbiased drug screening approaches, we discover Metformin,...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaoyan, Sun, Yaqin, Cen, Xufeng, Shan, Bing, Zhao, Qingwei, Xie, Tingxue, Wang, Zhe, Hou, Tingjun, Xue, Yu, Zhang, Mengmeng, Peng, Di, Sun, Qiming, Yi, Cong, Najafov, Ayaz, Xia, Hongguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464644/ https://www.ncbi.nlm.nih.gov/pubmed/34291435 http://dx.doi.org/10.1007/s13238-021-00858-3

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