The Impact of Tumor Edema on T2-Weighted 3T-MRI Invasive Breast Cancer Histological Characterization: A Pilot Radiomics Study

SIMPLE SUMMARY: Breast cancer is the most common cancer in women worldwide. Currently the use of MR is mandatory in staging phase. The standard protocol includes T2-weighted sequences for morphology and signal analysis, T1-weighted images for adding information (i.e., ematic or adipous components), diffusion-weighted sequences which provide information on tissue cellularity, and dynamic post-contrast sequences useful for detecting and locating lesions. Although not considered among the main prognostic factors in current guidelines, tumor-associated edema provides useful information on tumor aggressiveness, and has been shown to be associated with the main histological tumor characteristics. With this work, entitled “The Impact of Tumor Edema on T2-weighted 3T-MRI Invasive Breast Cancer Histological Characterization: a Pilot Radiomics Study”, we want to demonstrate that radiomics edema, based on algorithms that allow the extraction of imaging features not visible to the human eye, can further increase the accuracy in the prediction of histological factors compared to the use of traditional information only. ABSTRACT: Background: to evaluate the contribution of edema associated with histological features to the prediction of breast cancer (BC) prognosis using T2-weighted MRI radiomics. Methods: 160 patients who underwent staging 3T-MRI from January 2015 to January 2019, with 164 histologically proven invasive BC lesions, were retrospectively reviewed. Patient data (age, menopausal status, family history, hormone therapy), tumor MRI-features (location, margins, enhancement) and histological features (histological type, grading, ER, PgR, HER2, Ki-67 index) were collected. Of the 160 MRI exams, 120 were considered eligible, corresponding to 127 lesions. T2-MRI were used to identify edema, which was classified in four groups: peritumoral, pre-pectoral, subcutaneous, or diffuse. A semi-automatic segmentation of the edema was performed for each lesion, using 3D Slicer open-source software. Main radiomics features were extracted and selected using a wrapper selection method. A Random Forest type classifier was trained to measure the performance of predicting histological factors using semantic features (patient data and MRI features) alone and semantic features associated with edema radiomics features. Results: edema was absent in 37 lesions and present in 127 (62 peritumoral, 26 pre-pectoral, 16 subcutaneous, 23 diffuse). The AUC-classifier obtained by associating edema radiomics with semantic features was always higher compared to the AUC-classifier obtained from semantic features alone, for all five histological classes prediction (0.645 vs. 0.520 for histological type, 0.789 vs. 0.590 for grading, 0.487 vs. 0.466 for ER, 0.659 vs. 0.546 for PgR, and 0.62 vs. 0.573 for Ki67). Conclusions: radiomic features extracted from tumor edema contribute significantly to predicting tumor histology, increasing the accuracy obtained from the combination of patient clinical characteristics and breast imaging data.