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COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center

Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare t...

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Autores principales: Tummolo, Albina, Paterno, Giulia, Dicintio, Annamaria, Stefanizzi, Pasquale, Melpignano, Livio, Aricò, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464704/
https://www.ncbi.nlm.nih.gov/pubmed/34572213
http://dx.doi.org/10.3390/children8090781
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author Tummolo, Albina
Paterno, Giulia
Dicintio, Annamaria
Stefanizzi, Pasquale
Melpignano, Livio
Aricò, Maurizio
author_facet Tummolo, Albina
Paterno, Giulia
Dicintio, Annamaria
Stefanizzi, Pasquale
Melpignano, Livio
Aricò, Maurizio
author_sort Tummolo, Albina
collection PubMed
description Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare them with a matched control group. Among the total number of 272 patients actively followed at a referral center, 19 (7%) tested positive for SARS-CoV-2 between March 2020 and March 2021. Their median age was 16.2 years (range 1.4–32.8 years). In two-thirds of the cases, the source of infection was a family member; 12/19 patients (63%) were asymptomatic, only one required hospitalization, and none of them died. In our single-center experience, COVID-19 had a moderate impact on a relatively large cohort of patients with IMD, including children and young adults. The clinical course was very mild in all but one case. The proportion of symptomatic cases and the clinical course were comparable in patients with IMD and in a group of matched, non-IMD COVID-19 controls from the general population.
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spelling pubmed-84647042021-09-27 COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center Tummolo, Albina Paterno, Giulia Dicintio, Annamaria Stefanizzi, Pasquale Melpignano, Livio Aricò, Maurizio Children (Basel) Article Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare them with a matched control group. Among the total number of 272 patients actively followed at a referral center, 19 (7%) tested positive for SARS-CoV-2 between March 2020 and March 2021. Their median age was 16.2 years (range 1.4–32.8 years). In two-thirds of the cases, the source of infection was a family member; 12/19 patients (63%) were asymptomatic, only one required hospitalization, and none of them died. In our single-center experience, COVID-19 had a moderate impact on a relatively large cohort of patients with IMD, including children and young adults. The clinical course was very mild in all but one case. The proportion of symptomatic cases and the clinical course were comparable in patients with IMD and in a group of matched, non-IMD COVID-19 controls from the general population. MDPI 2021-09-06 /pmc/articles/PMC8464704/ /pubmed/34572213 http://dx.doi.org/10.3390/children8090781 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tummolo, Albina
Paterno, Giulia
Dicintio, Annamaria
Stefanizzi, Pasquale
Melpignano, Livio
Aricò, Maurizio
COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title_full COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title_fullStr COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title_full_unstemmed COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title_short COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
title_sort covid-19 and inherited metabolic disorders: one-year experience of a referral center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464704/
https://www.ncbi.nlm.nih.gov/pubmed/34572213
http://dx.doi.org/10.3390/children8090781
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