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COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center
Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464704/ https://www.ncbi.nlm.nih.gov/pubmed/34572213 http://dx.doi.org/10.3390/children8090781 |
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author | Tummolo, Albina Paterno, Giulia Dicintio, Annamaria Stefanizzi, Pasquale Melpignano, Livio Aricò, Maurizio |
author_facet | Tummolo, Albina Paterno, Giulia Dicintio, Annamaria Stefanizzi, Pasquale Melpignano, Livio Aricò, Maurizio |
author_sort | Tummolo, Albina |
collection | PubMed |
description | Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare them with a matched control group. Among the total number of 272 patients actively followed at a referral center, 19 (7%) tested positive for SARS-CoV-2 between March 2020 and March 2021. Their median age was 16.2 years (range 1.4–32.8 years). In two-thirds of the cases, the source of infection was a family member; 12/19 patients (63%) were asymptomatic, only one required hospitalization, and none of them died. In our single-center experience, COVID-19 had a moderate impact on a relatively large cohort of patients with IMD, including children and young adults. The clinical course was very mild in all but one case. The proportion of symptomatic cases and the clinical course were comparable in patients with IMD and in a group of matched, non-IMD COVID-19 controls from the general population. |
format | Online Article Text |
id | pubmed-8464704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84647042021-09-27 COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center Tummolo, Albina Paterno, Giulia Dicintio, Annamaria Stefanizzi, Pasquale Melpignano, Livio Aricò, Maurizio Children (Basel) Article Understanding the potential risks of patients with inherited metabolic disorder (IMD) exposed to the COVID-19 pandemic is an unmet need for those involved in their management. Here, we report on the incidence of COVID-19 in a cohort of patients with IMD treated at a children’s hospital and compare them with a matched control group. Among the total number of 272 patients actively followed at a referral center, 19 (7%) tested positive for SARS-CoV-2 between March 2020 and March 2021. Their median age was 16.2 years (range 1.4–32.8 years). In two-thirds of the cases, the source of infection was a family member; 12/19 patients (63%) were asymptomatic, only one required hospitalization, and none of them died. In our single-center experience, COVID-19 had a moderate impact on a relatively large cohort of patients with IMD, including children and young adults. The clinical course was very mild in all but one case. The proportion of symptomatic cases and the clinical course were comparable in patients with IMD and in a group of matched, non-IMD COVID-19 controls from the general population. MDPI 2021-09-06 /pmc/articles/PMC8464704/ /pubmed/34572213 http://dx.doi.org/10.3390/children8090781 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tummolo, Albina Paterno, Giulia Dicintio, Annamaria Stefanizzi, Pasquale Melpignano, Livio Aricò, Maurizio COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title | COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title_full | COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title_fullStr | COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title_full_unstemmed | COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title_short | COVID-19 and Inherited Metabolic Disorders: One-Year Experience of a Referral Center |
title_sort | covid-19 and inherited metabolic disorders: one-year experience of a referral center |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464704/ https://www.ncbi.nlm.nih.gov/pubmed/34572213 http://dx.doi.org/10.3390/children8090781 |
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