Diagnostic Strategies for Thyroid Nodules Based on Ultrasonographic Findings in Japan

SIMPLE SUMMARY: In recent years, the incidence of thyroid cancer has been increasing worldwide, mainly due to the widespread use of imaging examination methods, such as ultrasonography. In Japan, the risk of overdiagnosis due to the use of diagnostic imaging has been discussed since the 1990s, and measures have been taken to reduce the risk of overdiagnosis and overtreatment by establishing criteria for the implementation of fine needle aspiration cytology and non-surgical follow-up. This article outlines the diagnostic criteria and management guidelines in Japan in comparison with those published in other countries. ABSTRACT: In recent years, the incidence of thyroid cancer has been increasing worldwide, which is believed to be mainly due to the widespread use of imaging examinations, such as ultrasonography. In this context, ultrasonography has become increasingly important because it can evaluate not only the presence or absence of nodules, but also the detailed characteristics of the nodule, making it possible to diagnose benign or malignant nodules before cytology is performed. In Japan, the third edition of the sonographic diagnostic criteria for thyroid nodules is currently widely used, and its content is similar to that of recent meta-analyses and guidelines from medical societies in other countries. In addition, since overdiagnosis of very-low-risk thyroid cancer has recently become an issue, criteria for the implementation of fine needle aspiration cytology (FNAC) have been published by various countries. The Japan Society of Breast and Thyroid Sonology provides guidelines for FNAC implementation for solid and cystic nodules. In the United States, the ATA, NCCA, and ACR have published guidelines, whereas in Europe, the ESMO and ETA have done the same. All of these guidelines used to classify risk are based on nodule size and sonographic findings. This article outlines the diagnostic criteria and management guidelines in Japan in comparison with those published in other countries. Case studies using actual images were also performed to examine the differences in the FNAC guidelines.