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Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human β-Cells

Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells. Here, we evaluated the effects of GLP-1R agonism on insulin secretory granule (ISG) dynamics in primary β-cells isolated from human...

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Detalles Bibliográficos
Autores principales:	Ferri, Gianmarco, Tesi, Marta, Pesce, Luca, Bugliani, Marco, Grano, Francesca, Occhipinti, Margherita, Suleiman, Mara, De Luca, Carmela, Marselli, Lorella, Marchetti, Piero, Cardarelli, Francesco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464798/ https://www.ncbi.nlm.nih.gov/pubmed/34575477 http://dx.doi.org/10.3390/pharmaceutics13091403

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