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Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders

Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychotic plasmatic levels and, consequently, the biological effect could contribute to a deepe...

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Autores principales: Carrascal-Laso, Lorena, Isidoro-García, María, Ramos-Gallego, Ignacio, Franco-Martín, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464829/
https://www.ncbi.nlm.nih.gov/pubmed/34575384
http://dx.doi.org/10.3390/jcm10184275
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author Carrascal-Laso, Lorena
Isidoro-García, María
Ramos-Gallego, Ignacio
Franco-Martín, Manuel A.
author_facet Carrascal-Laso, Lorena
Isidoro-García, María
Ramos-Gallego, Ignacio
Franco-Martín, Manuel A.
author_sort Carrascal-Laso, Lorena
collection PubMed
description Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychotic plasmatic levels and, consequently, the biological effect could contribute to a deeper knowledge of interindividual antipsychotic treatment variability, prompting possible solutions. Considering this, this state of the art review aimed to summarize the current knowledge about the influence of the diverse characterized phenotypes on the metabolism of the most used second-generation antipsychotics. Forty studies describing different single nucleotide polymorphisms (SNPs) associated with the genes CYP1A2, CYP2D6, CYP3A4, CYP3A5, and ABCB1 and their influence on pharmacokinetics of olanzapine, clozapine, aripiprazole, risperidone, and quetiapine. Most of the authors concluded that although significant differences in the pharmacokinetic parameters between the different phenotypes could be observed, more thorough studies describing pharmacokinetic interactions and environmental conditions, among other variables, are needed to fully comprehend these pharmacogenetic interactions.
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spelling pubmed-84648292021-09-27 Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders Carrascal-Laso, Lorena Isidoro-García, María Ramos-Gallego, Ignacio Franco-Martín, Manuel A. J Clin Med Review Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychotic plasmatic levels and, consequently, the biological effect could contribute to a deeper knowledge of interindividual antipsychotic treatment variability, prompting possible solutions. Considering this, this state of the art review aimed to summarize the current knowledge about the influence of the diverse characterized phenotypes on the metabolism of the most used second-generation antipsychotics. Forty studies describing different single nucleotide polymorphisms (SNPs) associated with the genes CYP1A2, CYP2D6, CYP3A4, CYP3A5, and ABCB1 and their influence on pharmacokinetics of olanzapine, clozapine, aripiprazole, risperidone, and quetiapine. Most of the authors concluded that although significant differences in the pharmacokinetic parameters between the different phenotypes could be observed, more thorough studies describing pharmacokinetic interactions and environmental conditions, among other variables, are needed to fully comprehend these pharmacogenetic interactions. MDPI 2021-09-21 /pmc/articles/PMC8464829/ /pubmed/34575384 http://dx.doi.org/10.3390/jcm10184275 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carrascal-Laso, Lorena
Isidoro-García, María
Ramos-Gallego, Ignacio
Franco-Martín, Manuel A.
Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title_full Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title_fullStr Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title_full_unstemmed Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title_short Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders
title_sort review: influence of the cyp450 genetic variation on the treatment of psychotic disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464829/
https://www.ncbi.nlm.nih.gov/pubmed/34575384
http://dx.doi.org/10.3390/jcm10184275
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