Synthesis and In Vitro Evaluation of Novel Dopamine Receptor D(2) 3,4-dihydroquinolin-2(1H)-one Derivatives Related to Aripiprazole

In this pilot study, a series of new 3,4-dihydroquinolin-2(1H)-one derivatives as potential dopamine receptor D(2) (D(2)R) modulators were synthesized and evaluated in vitro. The preliminary structure–activity relationship disclosed that compound 5e exhibited the highest D(2)R affinity among the new...

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Detalles Bibliográficos
Autores principales: Juza, Radomir, Stefkova, Kristyna, Dehaen, Wim, Randakova, Alena, Petrasek, Tomas, Vojtechova, Iveta, Kobrlova, Tereza, Pulkrabkova, Lenka, Muckova, Lubica, Mecava, Marko, Prchal, Lukas, Mezeiova, Eva, Musilek, Kamil, Soukup, Ondrej, Korabecny, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464836/
https://www.ncbi.nlm.nih.gov/pubmed/34572475
http://dx.doi.org/10.3390/biom11091262

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