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D-2-Hydroxyglutarate in Glioma Biology

Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in glioma, which result in the accumulation of an “oncometabolite”, D-2-hydroxyglutarate (D-2-HG). Abnormally elevated D-2-HG levels result in a distinctive pattern in cancer biology, through competitively inhibiting α-ketoglu...

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Detalles Bibliográficos
Autores principales:	Chou, Fu-Ju, Liu, Yang, Lang, Fengchao, Yang, Chunzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464856/ https://www.ncbi.nlm.nih.gov/pubmed/34571995 http://dx.doi.org/10.3390/cells10092345

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