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3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464872/ https://www.ncbi.nlm.nih.gov/pubmed/34575497 http://dx.doi.org/10.3390/pharmaceutics13091421 |
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author | Xu, Xiaoyan Awwad, Sahar Diaz-Gomez, Luis Alvarez-Lorenzo, Carmen Brocchini, Steve Gaisford, Simon Goyanes, Alvaro Basit, Abdul W. |
author_facet | Xu, Xiaoyan Awwad, Sahar Diaz-Gomez, Luis Alvarez-Lorenzo, Carmen Brocchini, Steve Gaisford, Simon Goyanes, Alvaro Basit, Abdul W. |
author_sort | Xu, Xiaoyan |
collection | PubMed |
description | Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration. |
format | Online Article Text |
id | pubmed-8464872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84648722021-09-27 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery Xu, Xiaoyan Awwad, Sahar Diaz-Gomez, Luis Alvarez-Lorenzo, Carmen Brocchini, Steve Gaisford, Simon Goyanes, Alvaro Basit, Abdul W. Pharmaceutics Article Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration. MDPI 2021-09-08 /pmc/articles/PMC8464872/ /pubmed/34575497 http://dx.doi.org/10.3390/pharmaceutics13091421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xu, Xiaoyan Awwad, Sahar Diaz-Gomez, Luis Alvarez-Lorenzo, Carmen Brocchini, Steve Gaisford, Simon Goyanes, Alvaro Basit, Abdul W. 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title | 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title_full | 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title_fullStr | 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title_full_unstemmed | 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title_short | 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery |
title_sort | 3d printed punctal plugs for controlled ocular drug delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464872/ https://www.ncbi.nlm.nih.gov/pubmed/34575497 http://dx.doi.org/10.3390/pharmaceutics13091421 |
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