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3D Printed Punctal Plugs for Controlled Ocular Drug Delivery

Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digit...

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Autores principales: Xu, Xiaoyan, Awwad, Sahar, Diaz-Gomez, Luis, Alvarez-Lorenzo, Carmen, Brocchini, Steve, Gaisford, Simon, Goyanes, Alvaro, Basit, Abdul W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464872/
https://www.ncbi.nlm.nih.gov/pubmed/34575497
http://dx.doi.org/10.3390/pharmaceutics13091421
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author Xu, Xiaoyan
Awwad, Sahar
Diaz-Gomez, Luis
Alvarez-Lorenzo, Carmen
Brocchini, Steve
Gaisford, Simon
Goyanes, Alvaro
Basit, Abdul W.
author_facet Xu, Xiaoyan
Awwad, Sahar
Diaz-Gomez, Luis
Alvarez-Lorenzo, Carmen
Brocchini, Steve
Gaisford, Simon
Goyanes, Alvaro
Basit, Abdul W.
author_sort Xu, Xiaoyan
collection PubMed
description Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration.
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spelling pubmed-84648722021-09-27 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery Xu, Xiaoyan Awwad, Sahar Diaz-Gomez, Luis Alvarez-Lorenzo, Carmen Brocchini, Steve Gaisford, Simon Goyanes, Alvaro Basit, Abdul W. Pharmaceutics Article Dry eye disease is a common ocular disorder that is characterised by tear deficiency or excessive tear evaporation. Current treatment involves the use of eye drops; however, therapeutic efficacy is limited because of poor ocular bioavailability of topically applied formulations. In this study, digital light processing (DLP) 3D printing was employed to develop dexamethasone-loaded punctal plugs. Punctal plugs with different drug loadings were fabricated using polyethylene glycol diacrylate (PEGDA) and polyethylene glycol 400 (PEG 400) to create a semi-interpenetrating network (semi-IPN). Drug-loaded punctal plugs were characterised in terms of physical characteristics (XRD and DSC), potential drug-photopolymer interactions (FTIR), drug release profile, and cytocompatibility. In vitro release kinetics of the punctal plugs were evaluated using an in-house flow rig model that mimics the subconjunctival space. The results showed sustained release of dexamethasone for up to 7 days from punctal plugs made with 20% w/w PEG 400 and 80% w/w PEGDA, while punctal plugs made with 100% PEGDA exhibited prolonged releases for more than 21 days. Herein, our study demonstrates that DLP 3D printing represents a potential manufacturing platform for fabricating personalised drug-loaded punctal plugs with extended release characteristics for ocular administration. MDPI 2021-09-08 /pmc/articles/PMC8464872/ /pubmed/34575497 http://dx.doi.org/10.3390/pharmaceutics13091421 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiaoyan
Awwad, Sahar
Diaz-Gomez, Luis
Alvarez-Lorenzo, Carmen
Brocchini, Steve
Gaisford, Simon
Goyanes, Alvaro
Basit, Abdul W.
3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title_full 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title_fullStr 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title_full_unstemmed 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title_short 3D Printed Punctal Plugs for Controlled Ocular Drug Delivery
title_sort 3d printed punctal plugs for controlled ocular drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464872/
https://www.ncbi.nlm.nih.gov/pubmed/34575497
http://dx.doi.org/10.3390/pharmaceutics13091421
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