Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings

Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential...

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Autores principales: Aksenov, Alexander V., Kirilov, Nikita K., Aksenov, Nicolai A., Aksenov, Dmitrii A., Sorokina, Elena A., Lower, Carolyn, Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464891/
https://www.ncbi.nlm.nih.gov/pubmed/34577163
http://dx.doi.org/10.3390/molecules26185692
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author Aksenov, Alexander V.
Kirilov, Nikita K.
Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Sorokina, Elena A.
Lower, Carolyn
Rubin, Michael
author_facet Aksenov, Alexander V.
Kirilov, Nikita K.
Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Sorokina, Elena A.
Lower, Carolyn
Rubin, Michael
author_sort Aksenov, Alexander V.
collection PubMed
description Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents.
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spelling pubmed-84648912021-09-27 Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings Aksenov, Alexander V. Kirilov, Nikita K. Aksenov, Nicolai A. Aksenov, Dmitrii A. Sorokina, Elena A. Lower, Carolyn Rubin, Michael Molecules Article Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed for an innovative synthetic protocol employing simultaneous or sequential annulation of two different heterocyclic cores, affording [1,2,4]triazolo[4,3-a]quinolines with 1,3,4-oxadiazole substituents. MDPI 2021-09-20 /pmc/articles/PMC8464891/ /pubmed/34577163 http://dx.doi.org/10.3390/molecules26185692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksenov, Alexander V.
Kirilov, Nikita K.
Aksenov, Nicolai A.
Aksenov, Dmitrii A.
Sorokina, Elena A.
Lower, Carolyn
Rubin, Michael
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title_full Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title_fullStr Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title_full_unstemmed Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title_short Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
title_sort electrophilically activated nitroalkanes in double annulation of [1,2,4]triazolo[4,3-a]quinolines and 1,3,4-oxadiazole rings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464891/
https://www.ncbi.nlm.nih.gov/pubmed/34577163
http://dx.doi.org/10.3390/molecules26185692
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