Cargando…
Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats
Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464928/ https://www.ncbi.nlm.nih.gov/pubmed/34578849 http://dx.doi.org/10.3390/nu13092971 |
_version_ | 1784572740340023296 |
---|---|
author | Robles-Vera, Iñaki de la Visitación, Néstor Toral, Marta Sánchez, Manuel Romero, Miguel Gómez-Guzmán, Manuel Vargas, Félix Duarte, Juan Jiménez, Rosario |
author_facet | Robles-Vera, Iñaki de la Visitación, Néstor Toral, Marta Sánchez, Manuel Romero, Miguel Gómez-Guzmán, Manuel Vargas, Félix Duarte, Juan Jiménez, Rosario |
author_sort | Robles-Vera, Iñaki |
collection | PubMed |
description | Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure, improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta. These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension. |
format | Online Article Text |
id | pubmed-8464928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84649282021-09-27 Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats Robles-Vera, Iñaki de la Visitación, Néstor Toral, Marta Sánchez, Manuel Romero, Miguel Gómez-Guzmán, Manuel Vargas, Félix Duarte, Juan Jiménez, Rosario Nutrients Article Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure, improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta. These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension. MDPI 2021-08-26 /pmc/articles/PMC8464928/ /pubmed/34578849 http://dx.doi.org/10.3390/nu13092971 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Robles-Vera, Iñaki de la Visitación, Néstor Toral, Marta Sánchez, Manuel Romero, Miguel Gómez-Guzmán, Manuel Vargas, Félix Duarte, Juan Jiménez, Rosario Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title | Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title_full | Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title_fullStr | Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title_full_unstemmed | Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title_short | Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats |
title_sort | changes in gut microbiota induced by doxycycline influence in vascular function and development of hypertension in doca-salt rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464928/ https://www.ncbi.nlm.nih.gov/pubmed/34578849 http://dx.doi.org/10.3390/nu13092971 |
work_keys_str_mv | AT roblesverainaki changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT delavisitacionnestor changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT toralmarta changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT sanchezmanuel changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT romeromiguel changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT gomezguzmanmanuel changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT vargasfelix changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT duartejuan changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats AT jimenezrosario changesingutmicrobiotainducedbydoxycyclineinfluenceinvascularfunctionanddevelopmentofhypertensionindocasaltrats |