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Antimicrobial Peptides and Their Applications in Biomedical Sector

In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicr...

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Autores principales: Sultana, Afreen, Luo, Hongrong, Ramakrishna, Seeram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465024/
https://www.ncbi.nlm.nih.gov/pubmed/34572676
http://dx.doi.org/10.3390/antibiotics10091094
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author Sultana, Afreen
Luo, Hongrong
Ramakrishna, Seeram
author_facet Sultana, Afreen
Luo, Hongrong
Ramakrishna, Seeram
author_sort Sultana, Afreen
collection PubMed
description In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNFα, IL-8, and IL-1β, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs.
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spelling pubmed-84650242021-09-27 Antimicrobial Peptides and Their Applications in Biomedical Sector Sultana, Afreen Luo, Hongrong Ramakrishna, Seeram Antibiotics (Basel) Review In a report by WHO (2014), it was stated that antimicrobial resistance is an arising challenge that needs to be resolved. This resistance is a critical issue in terms of disease or infection treatment and is usually caused due to mutation, gene transfer, long-term usage or inadequate use of antimicrobials, survival of microbes after consumption of antimicrobials, and the presence of antimicrobials in agricultural feeds. One of the solutions to this problem is antimicrobial peptides (AMPs), which are ubiquitously present in the environment. These peptides are of concern due to their special mode of action against a wide spectrum of infections and health-related problems. The biomedical field has the highest need of AMPs as it possesses prominent desirable activity against HIV-1, skin cancer, breast cancer, in Behcet’s disease treatment, as well as in reducing the release of inflammatory cells such as TNFα, IL-8, and IL-1β, enhancing the production of anti-inflammatory cytokines such as IL-10 and GM-CSF, and in wound healing properties. This review has highlighted all the major functions and applications of AMPs in the biomedical field and concludes the future potential of AMPs. MDPI 2021-09-10 /pmc/articles/PMC8465024/ /pubmed/34572676 http://dx.doi.org/10.3390/antibiotics10091094 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sultana, Afreen
Luo, Hongrong
Ramakrishna, Seeram
Antimicrobial Peptides and Their Applications in Biomedical Sector
title Antimicrobial Peptides and Their Applications in Biomedical Sector
title_full Antimicrobial Peptides and Their Applications in Biomedical Sector
title_fullStr Antimicrobial Peptides and Their Applications in Biomedical Sector
title_full_unstemmed Antimicrobial Peptides and Their Applications in Biomedical Sector
title_short Antimicrobial Peptides and Their Applications in Biomedical Sector
title_sort antimicrobial peptides and their applications in biomedical sector
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465024/
https://www.ncbi.nlm.nih.gov/pubmed/34572676
http://dx.doi.org/10.3390/antibiotics10091094
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