Cargando…

Expression Analysis of α5 Integrin Subunit Reveals Its Upregulation as a Negative Prognostic Biomarker for Glioblastoma

Integrin α5β1 was suggested to be involved in glioblastoma (GBM) aggressiveness and treatment resistance through preclinical studies and genomic analysis in patients. However, further protein expression data are still required to confirm this hypothesis. In the present study, we investigated by immu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Etienne-Selloum, Nelly, Prades, Julien, Bello-Roufai, Diana, Boone, Mathieu, Sevestre, Henri, Trudel, Stéphanie, Caillet, Pascal, Coutte, Alexandre, Desenclos, Christine, Constans, Jean-Marc, Martin, Sophie, Choulier, Laurence, Chauffert, Bruno, Dontenwill, Monique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465081/ https://www.ncbi.nlm.nih.gov/pubmed/34577582 http://dx.doi.org/10.3390/ph14090882

Ejemplares similares

A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials
por: Cruz Da Silva, Elisabete, et al.
Publicado: (2021)

Temozolomide and Bevacizumab Induction before Chemoradiotherapy in Patients with Bulky Glioblastoma and/or with Severe Neurological Impairment
por: Darmon, Ilan, et al.
Publicado: (2017)

Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells
por: Renner, Guillaume, et al.
Publicado: (2016)

Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma
por: Loriguet, Lea, et al.
Publicado: (2018)

Role of Integrins in Resistance to Therapies Targeting Growth Factor Receptors in Cancer
por: Cruz da Silva, Elisabete, et al.
Publicado: (2019)

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin
por: Sani, Saidu, et al.
Publicado: (2022)

Bioimaging Nucleic-Acid Aptamers with Different Specificities in Human Glioblastoma Tissues Highlights Tumoral Heterogeneity
por: Cruz Da Silva, Elisabete, et al.
Publicado: (2022)

Selection of Nucleic Acid Aptamers Targeting Tumor Cell-Surface Protein Biomarkers
por: Mercier, Marie-Cécile, et al.
Publicado: (2017)

Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period
por: Beddok, Arnaud, et al.
Publicado: (2021)

RNA Aptamers Targeting Integrin α5β1 as Probes for Cyto- and Histofluorescence in Glioblastoma
por: Fechter, Pierre, et al.
Publicado: (2019)

Sustained Response of a Clivus Chordoma to Erlotinib after Imatinib Failure
por: Houessinon, Aline, et al.
Publicado: (2015)

Integrins and p53 pathways in glioblastoma resistance to temozolomide
por: Martin, Sophie, et al.
Publicado: (2012)

Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
por: Chehimi, Mohamad, et al.
Publicado: (2016)

Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
por: Schaffner, Florence, et al.
Publicado: (2013)

Upfront Bevacizumab and Temozolomide or Fotemustine before Radiotherapy for Patients with Glioblastoma and Severe Neurological Impairment at Diagnosis
por: Bihan, Celina, et al.
Publicado: (2012)

β1 Integrins as Therapeutic Targets to Disrupt Hallmarks of Cancer
por: Blandin, Anne-Florence, et al.
Publicado: (2015)

Blocking EREG/GPX4 Sensitizes Head and Neck Cancer to Cetuximab through Ferroptosis Induction
por: Jehl, Aude, et al.
Publicado: (2023)

Evaluation of Proton MR Spectroscopy for the Study of the Tongue Tissue in Healthy Subjects and Patients With Tongue Squamous Cell Carcinoma: Preliminary Findings
por: Boussida, Salem, et al.
Publicado: (2022)

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary
por: Kraus, Francois, et al.
Publicado: (2020)

Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer
por: Eve, Louisane, et al.
Publicado: (2020)

Comprehensive Characterization of Integrin Subunit Genes in Human Cancers
por: Cui, Kaisa, et al.
Publicado: (2021)

Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients
por: He, Jing, et al.
Publicado: (2018)

Two Cases of Fatal Encephalopathy Related to Ifosfamide: An Adverse Role of Aprepitant?
por: Séjourné, Alice, et al.
Publicado: (2014)

Relationships between the physicochemical properties of an amphiphilic triblock copolymers/DNA complexes and their intramuscular transfection efficiency
por: Bello-Roufaï, Mahajoub, et al.
Publicado: (2007)

Cav1/EREG/YAP Axis in the Treatment Resistance of Cav1-Expressing Head and Neck Squamous Cell Carcinoma
por: Burgy, Mickaël, et al.
Publicado: (2021)

Proteolytic processing of endogenous and recombinant beta 4 integrin subunit
Publicado: (1992)

Functional role of the cytoplasmic domain of the integrin alpha 5 subunit
Publicado: (1993)

Integrin α1 subunit is up-regulated in colorectal cancer
por: Boudjadi, Salah, et al.
Publicado: (2013)

Integrin subunit beta 8 contributes to lenvatinib resistance in HCC
por: Hou, Wei, et al.
Publicado: (2022)

The clinical response to vemurafenib in a patient with a rare BRAF(V600DK601del) mutation-positive melanoma
por: Trudel, Stéphanie, et al.
Publicado: (2014)

Eruptive melanocytic nevi associated with ponatinib
por: Devred, Inès, et al.
Publicado: (2018)

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties
por: Jung, Alain C., et al.
Publicado: (2015)

Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Publicado: (1992)

PTHrP increases transcriptional activity of the integrin subunit α(5)
por: Anderson, J A, et al.
Publicado: (2007)

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro
Publicado: (1990)

Structure/function analysis of the integrin beta 1 subunit by epitope mapping
Publicado: (1993)

On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation
por: Pagani, Giulia, et al.
Publicado: (2018)

Induction of migration of periodontal ligament cells by selective regulation of integrin subunits
por: Kawamura, Mari, et al.
Publicado: (2018)

Mast Cell Protease 7 Promotes Angiogenesis by Degradation of Integrin Subunits
por: de Souza Junior, Devandir A., et al.
Publicado: (2019)

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_uvolvb6tccp1g2vjnb16nrolmi