Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3

Eight new compounds, including two sambutoxin derivatives (1–2), two highly oxygenated cyclopentenones (7–8), four highly oxygenated cyclohexenones (9–12), together with four known sambutoxin derivatives (3–6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidanc...

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Autores principales: Yang, Wencong, Tan, Qi, Yin, Yihao, Chen, Yan, Zhang, Yi, Wu, Jianying, Gao, Leyao, Wang, Bo, She, Zhigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465095/
https://www.ncbi.nlm.nih.gov/pubmed/34564154
http://dx.doi.org/10.3390/md19090492
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author Yang, Wencong
Tan, Qi
Yin, Yihao
Chen, Yan
Zhang, Yi
Wu, Jianying
Gao, Leyao
Wang, Bo
She, Zhigang
author_facet Yang, Wencong
Tan, Qi
Yin, Yihao
Chen, Yan
Zhang, Yi
Wu, Jianying
Gao, Leyao
Wang, Bo
She, Zhigang
author_sort Yang, Wencong
collection PubMed
description Eight new compounds, including two sambutoxin derivatives (1–2), two highly oxygenated cyclopentenones (7–8), four highly oxygenated cyclohexenones (9–12), together with four known sambutoxin derivatives (3–6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, (13)C NMR calculation, and DP4+ analysis. In bioassays, compounds 1–5 displayed better α-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC(50) = 80.8 ± 0.3 μM), and the IC(50) value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM.
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spelling pubmed-84650952021-09-27 Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3 Yang, Wencong Tan, Qi Yin, Yihao Chen, Yan Zhang, Yi Wu, Jianying Gao, Leyao Wang, Bo She, Zhigang Mar Drugs Article Eight new compounds, including two sambutoxin derivatives (1–2), two highly oxygenated cyclopentenones (7–8), four highly oxygenated cyclohexenones (9–12), together with four known sambutoxin derivatives (3–6), were isolated from semimangrove endophytic fungus Talaromyces sp. CY-3, under the guidance of molecular networking. The structures of new isolates were elucidated by analysis of detailed spectroscopic data, ECD spectra, chemical hydrolysis, (13)C NMR calculation, and DP4+ analysis. In bioassays, compounds 1–5 displayed better α-glucosidase inhibitory activity than the positive control 1-deoxynojirimycin (IC(50) = 80.8 ± 0.3 μM), and the IC(50) value was in the range of 12.6 ± 0.9 to 57.3 ± 1.3 μM. MDPI 2021-08-28 /pmc/articles/PMC8465095/ /pubmed/34564154 http://dx.doi.org/10.3390/md19090492 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Wencong
Tan, Qi
Yin, Yihao
Chen, Yan
Zhang, Yi
Wu, Jianying
Gao, Leyao
Wang, Bo
She, Zhigang
Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title_full Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title_fullStr Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title_full_unstemmed Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title_short Secondary Metabolites with α-Glucosidase Inhibitory Activity from Mangrove Endophytic Fungus Talaromyces sp. CY-3
title_sort secondary metabolites with α-glucosidase inhibitory activity from mangrove endophytic fungus talaromyces sp. cy-3
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465095/
https://www.ncbi.nlm.nih.gov/pubmed/34564154
http://dx.doi.org/10.3390/md19090492
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