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Cannabidiol Selectively Binds to the Voltage-Gated Sodium Channel Na(v)1.4 in Its Slow-Inactivated State and Inhibits Sodium Current

Cannabidiol (CBD), one of the cannabinoids from the cannabis plant, can relieve the myotonia resulting from sodium channelopathy, which manifests as repetitive discharges of muscle membrane. We investigated the binding kinetics of CBD to Na(v)1.4 channels on the muscle membrane. The binding affinity...

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Detalles Bibliográficos
Autores principales:	Huang, Chiung-Wei, Lin, Pi-Chen, Chen, Jian-Lin, Lee, Ming-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465134/ https://www.ncbi.nlm.nih.gov/pubmed/34572327 http://dx.doi.org/10.3390/biomedicines9091141

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