Sustained Intra-Articular Release and Biocompatibility of Tacrolimus (FK506) Loaded Monospheres Composed of [PDLA-PEG(1000)]-b-[PLLA] Multi-Block Copolymers in Healthy Horse Joints

There is an increasing interest in controlled release systems for local therapy in the treatment of human and equine joint diseases, aiming for optimal intra-articular concentrations with no systemic side effects. In this study, the intra-articular tolerability and suitability for local and sustaine...

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Detalles Bibliográficos
Autores principales: Cokelaere, Stefan M., Groen, Wilhelmina M.G.A.C., Plomp, Saskia G.M., de Grauw, Janny C., van Midwoud, Paul M., Weinans, Harrie H., van de Lest, Chris H.A., Tryfonidou, Marianna A., van Weeren, P. René, Korthagen, Nicoline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465142/
https://www.ncbi.nlm.nih.gov/pubmed/34575514
http://dx.doi.org/10.3390/pharmaceutics13091438

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