Cargando…
Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma
Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment f...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465220/ https://www.ncbi.nlm.nih.gov/pubmed/34575840 http://dx.doi.org/10.3390/ijms22189673 |
_version_ | 1784572816095444992 |
---|---|
author | Ruiz-Garcia, Henry Ramirez-Loera, Cristopher Malouff, Timothy D. Seneviratne, Danushka S. Palmer, Joshua D. Trifiletti, Daniel M. |
author_facet | Ruiz-Garcia, Henry Ramirez-Loera, Cristopher Malouff, Timothy D. Seneviratne, Danushka S. Palmer, Joshua D. Trifiletti, Daniel M. |
author_sort | Ruiz-Garcia, Henry |
collection | PubMed |
description | Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment failure, and different therapeutic strategies are aimed at overcoming it. Among these strategies, nanomedicine has advantages over conventional tumor therapeutics, including improvements in drug delivery and enhanced antitumor properties. Radiosensitizing strategies using nanoparticles (NP) are actively under study and hold promise to improve the treatment response. We aim to describe the basis of nanomedicine for GBM treatment, current evidence in radiosensitization efforts using nanoparticles, and novel strategies, such as preoperative radiation, that could be synergized with nanoradiosensitizers. |
format | Online Article Text |
id | pubmed-8465220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84652202021-09-27 Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma Ruiz-Garcia, Henry Ramirez-Loera, Cristopher Malouff, Timothy D. Seneviratne, Danushka S. Palmer, Joshua D. Trifiletti, Daniel M. Int J Mol Sci Review Radiotherapy (RT) is one of the cornerstones in the current treatment paradigm for glioblastoma (GBM). However, little has changed in the management of GBM since the establishment of the current protocol in 2005, and the prognosis remains grim. Radioresistance is one of the hallmarks for treatment failure, and different therapeutic strategies are aimed at overcoming it. Among these strategies, nanomedicine has advantages over conventional tumor therapeutics, including improvements in drug delivery and enhanced antitumor properties. Radiosensitizing strategies using nanoparticles (NP) are actively under study and hold promise to improve the treatment response. We aim to describe the basis of nanomedicine for GBM treatment, current evidence in radiosensitization efforts using nanoparticles, and novel strategies, such as preoperative radiation, that could be synergized with nanoradiosensitizers. MDPI 2021-09-07 /pmc/articles/PMC8465220/ /pubmed/34575840 http://dx.doi.org/10.3390/ijms22189673 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ruiz-Garcia, Henry Ramirez-Loera, Cristopher Malouff, Timothy D. Seneviratne, Danushka S. Palmer, Joshua D. Trifiletti, Daniel M. Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title | Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title_full | Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title_fullStr | Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title_full_unstemmed | Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title_short | Novel Strategies for Nanoparticle-Based Radiosensitization in Glioblastoma |
title_sort | novel strategies for nanoparticle-based radiosensitization in glioblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465220/ https://www.ncbi.nlm.nih.gov/pubmed/34575840 http://dx.doi.org/10.3390/ijms22189673 |
work_keys_str_mv | AT ruizgarciahenry novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma AT ramirezloeracristopher novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma AT maloufftimothyd novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma AT seneviratnedanushkas novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma AT palmerjoshuad novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma AT trifilettidanielm novelstrategiesfornanoparticlebasedradiosensitizationinglioblastoma |