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Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction

We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluated on the day before discharge. The primary endpoi...

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Autores principales: García-Blas, Sergio, Bonanad, Clara, Fernández-Cisnal, Agustín, Sastre-Arbona, Clara, Ruescas-Nicolau, Maria-Arantzazu, González D’Gregorio, Jessika, Valero, Ernesto, Miñana, Gema, Palau, Patricia, Tarazona-Santabalbina, Francisco J., Ruiz Ros, Vicente, Núñez, Julio, Sanchis, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465296/
https://www.ncbi.nlm.nih.gov/pubmed/34575389
http://dx.doi.org/10.3390/jcm10184278
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author García-Blas, Sergio
Bonanad, Clara
Fernández-Cisnal, Agustín
Sastre-Arbona, Clara
Ruescas-Nicolau, Maria-Arantzazu
González D’Gregorio, Jessika
Valero, Ernesto
Miñana, Gema
Palau, Patricia
Tarazona-Santabalbina, Francisco J.
Ruiz Ros, Vicente
Núñez, Julio
Sanchis, Juan
author_facet García-Blas, Sergio
Bonanad, Clara
Fernández-Cisnal, Agustín
Sastre-Arbona, Clara
Ruescas-Nicolau, Maria-Arantzazu
González D’Gregorio, Jessika
Valero, Ernesto
Miñana, Gema
Palau, Patricia
Tarazona-Santabalbina, Francisco J.
Ruiz Ros, Vicente
Núñez, Julio
Sanchis, Juan
author_sort García-Blas, Sergio
collection PubMed
description We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluated on the day before discharge. The primary endpoint was number of days alive and out of hospital (DAOH) during the first 800 days. Secondary endpoints were mortality and a composite of mortality and reinfarction. Frailty was diagnosed in 58% and 34% of patients using the FFS and CFS scales, respectively. During the first 800 days 34 deaths and 137 admissions occurred. The number of DAOH decreased significantly with increasing scores of both FFS (p < 0.001) and CFS (p = 0.049). In multivariate analysis, only the highest scores (FFS = 5, CFS ≥ 6) were independently associated with fewer DAOH. At a median follow-up of 946 days, frailty assessed both by FFS and CFS was independently associated with death and MI (HR = 2.70 95%CI = 1.32–5.51 p = 0.001; HR = 2.01 95%CI = 1.1–3.66 p = 0.023, respectively), whereas all-cause mortality was only associated with FFS (HR = 1.51 95%CI = 1.08–2.10 p = 0.015). Frailty by FFS or CFS is independently associated with shorter number DAOH post-MI. Likewise, frailty assessed by either scale is associated with a higher rate of death and reinfarction, whereas FFS outperforms CFS for mortality prediction.
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spelling pubmed-84652962021-09-27 Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction García-Blas, Sergio Bonanad, Clara Fernández-Cisnal, Agustín Sastre-Arbona, Clara Ruescas-Nicolau, Maria-Arantzazu González D’Gregorio, Jessika Valero, Ernesto Miñana, Gema Palau, Patricia Tarazona-Santabalbina, Francisco J. Ruiz Ros, Vicente Núñez, Julio Sanchis, Juan J Clin Med Article We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluated on the day before discharge. The primary endpoint was number of days alive and out of hospital (DAOH) during the first 800 days. Secondary endpoints were mortality and a composite of mortality and reinfarction. Frailty was diagnosed in 58% and 34% of patients using the FFS and CFS scales, respectively. During the first 800 days 34 deaths and 137 admissions occurred. The number of DAOH decreased significantly with increasing scores of both FFS (p < 0.001) and CFS (p = 0.049). In multivariate analysis, only the highest scores (FFS = 5, CFS ≥ 6) were independently associated with fewer DAOH. At a median follow-up of 946 days, frailty assessed both by FFS and CFS was independently associated with death and MI (HR = 2.70 95%CI = 1.32–5.51 p = 0.001; HR = 2.01 95%CI = 1.1–3.66 p = 0.023, respectively), whereas all-cause mortality was only associated with FFS (HR = 1.51 95%CI = 1.08–2.10 p = 0.015). Frailty by FFS or CFS is independently associated with shorter number DAOH post-MI. Likewise, frailty assessed by either scale is associated with a higher rate of death and reinfarction, whereas FFS outperforms CFS for mortality prediction. MDPI 2021-09-21 /pmc/articles/PMC8465296/ /pubmed/34575389 http://dx.doi.org/10.3390/jcm10184278 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Blas, Sergio
Bonanad, Clara
Fernández-Cisnal, Agustín
Sastre-Arbona, Clara
Ruescas-Nicolau, Maria-Arantzazu
González D’Gregorio, Jessika
Valero, Ernesto
Miñana, Gema
Palau, Patricia
Tarazona-Santabalbina, Francisco J.
Ruiz Ros, Vicente
Núñez, Julio
Sanchis, Juan
Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title_full Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title_fullStr Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title_full_unstemmed Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title_short Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction
title_sort frailty scales for prognosis assessment of older adult patients after acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465296/
https://www.ncbi.nlm.nih.gov/pubmed/34575389
http://dx.doi.org/10.3390/jcm10184278
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