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Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV

The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate–containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovi...

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Autores principales: Castillo-Mancilla, Jose R, Morrow, Mary, Coyle, Ryan P, Coleman, Stacey S, Zheng, Jia-Hua, Ellison, Lucas, Bushman, Lane R, Kiser, Jennifer J, Anderson, Peter L, MaWhinney, Samantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465325/
https://www.ncbi.nlm.nih.gov/pubmed/34584902
http://dx.doi.org/10.1093/ofid/ofab463
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author Castillo-Mancilla, Jose R
Morrow, Mary
Coyle, Ryan P
Coleman, Stacey S
Zheng, Jia-Hua
Ellison, Lucas
Bushman, Lane R
Kiser, Jennifer J
Anderson, Peter L
MaWhinney, Samantha
author_facet Castillo-Mancilla, Jose R
Morrow, Mary
Coyle, Ryan P
Coleman, Stacey S
Zheng, Jia-Hua
Ellison, Lucas
Bushman, Lane R
Kiser, Jennifer J
Anderson, Peter L
MaWhinney, Samantha
author_sort Castillo-Mancilla, Jose R
collection PubMed
description The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate–containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800–1650; 800–1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2–3.1), 2.4 (95% CI, 1.1–5.0), and 4.6 (95% CI, 2.2–9.9), respectively. This suggests that adherence could impact LLV.
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spelling pubmed-84653252021-09-27 Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV Castillo-Mancilla, Jose R Morrow, Mary Coyle, Ryan P Coleman, Stacey S Zheng, Jia-Hua Ellison, Lucas Bushman, Lane R Kiser, Jennifer J Anderson, Peter L MaWhinney, Samantha Open Forum Infect Dis Brief Reports The drivers of low-level viremia (LLV) between 20 and 200 copies/mL remain unclear. In 1042 person-visits from 497 persons with HIV on tenofovir disoproxil fumarate–containing antiretroviral therapy (ART), the association between LLV and cumulative antiretroviral adherence (quantified using tenofovir diphosphate [TFV-DP] in dried blood spots) was assessed. Lower TFV-DP levels were associated with higher odds of LLV. As TFV-DP (fmol/punch) categories decreased from >1650 to 800–1650; 800–1650 to <800; and >1650 to <800, the adjusted odds ratios for LLV vs HIV VL <20 copies/mL were 2.0 (95% CI, 1.2–3.1), 2.4 (95% CI, 1.1–5.0), and 4.6 (95% CI, 2.2–9.9), respectively. This suggests that adherence could impact LLV. Oxford University Press 2021-09-17 /pmc/articles/PMC8465325/ /pubmed/34584902 http://dx.doi.org/10.1093/ofid/ofab463 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Castillo-Mancilla, Jose R
Morrow, Mary
Coyle, Ryan P
Coleman, Stacey S
Zheng, Jia-Hua
Ellison, Lucas
Bushman, Lane R
Kiser, Jennifer J
Anderson, Peter L
MaWhinney, Samantha
Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title_full Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title_fullStr Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title_full_unstemmed Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title_short Low-Level Viremia Is Associated With Cumulative Adherence to Antiretroviral Therapy in Persons With HIV
title_sort low-level viremia is associated with cumulative adherence to antiretroviral therapy in persons with hiv
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465325/
https://www.ncbi.nlm.nih.gov/pubmed/34584902
http://dx.doi.org/10.1093/ofid/ofab463
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