Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet

Several surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscl...

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Detalles Bibliográficos
Autores principales: Pérez-Arana, Gonzalo-Martín, Fernández-Vivero, José, Camacho-Ramírez, Alonso, Díaz Gómez, Alfredo, Bancalero de los Reyes, José, Ribelles-García, Antonio, Almorza-Gomar, David, Carrasco-Molinillo, Carmen, Prada-Oliveira, José-Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465472/
https://www.ncbi.nlm.nih.gov/pubmed/34575329
http://dx.doi.org/10.3390/jcm10184217
Descripción
Sumario:Several surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscle or fat, have been studied intensively after bariatric surgery. These effects on endocrine-cell populations in the pancreas have been less well studied. We gathered the existing data on these pancreatic-cell populations after the two most common types of bariatric surgery, the sleeve gastrectomy (SG) and the roux-en-Y gastric bypass (RYGB), with the aim to explain the pathophysiological mechanisms underlying these surgeries and to improve their outcome.

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