Pathogenesis and Molecular Mechanisms of Anderson–Fabry Disease and Possible New Molecular Addressed Therapeutic Strategies

Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element characterizing Fabry disease due to a hereditary deficiency α-galactosidase A (GLA) enzyme. The accumulation of Gb3 causes lyso...

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Detalles Bibliográficos
Autores principales: Tuttolomondo, Antonino, Simonetta, Irene, Riolo, Renata, Todaro, Federica, Di Chiara, Tiziana, Miceli, Salvatore, Pinto, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465525/
https://www.ncbi.nlm.nih.gov/pubmed/34576250
http://dx.doi.org/10.3390/ijms221810088

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