Cargando…

Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey

Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Hyemin, Baek, Sun-Young, Kim, Seon-Woo, Park, Eun-Jung, Kim, Hyungjin, Lee, Jaejoon, Jeon, Chan-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465554/
https://www.ncbi.nlm.nih.gov/pubmed/34577876
http://dx.doi.org/10.3390/medicina57090953
_version_ 1784572905344991232
author Jeong, Hyemin
Baek, Sun-Young
Kim, Seon-Woo
Park, Eun-Jung
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan-Hong
author_facet Jeong, Hyemin
Baek, Sun-Young
Kim, Seon-Woo
Park, Eun-Jung
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan-Hong
author_sort Jeong, Hyemin
collection PubMed
description Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population.
format Online
Article
Text
id pubmed-8465554
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84655542021-09-27 Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey Jeong, Hyemin Baek, Sun-Young Kim, Seon-Woo Park, Eun-Jung Kim, Hyungjin Lee, Jaejoon Jeon, Chan-Hong Medicina (Kaunas) Article Background and Objectives: Hyperuricemia is associated with several comorbidities. The association between uric acid (UA) and pulmonary function is still a controversial issue. This study evaluated the gender-specific association of serum UA and pulmonary function. Materials and Methods: A total of 3177 (weighted n = 19,770,902) participants aged 40 years or older were selected from the 2016 Korean National Health and Nutrition Examination Survey and included. Results: Female participants with hyperuricemia were older than participants with normouricemia. Body mass index (BMI), mean arterial pressure (MAP), hemoglobin A1c (HbA1c), and estimated glomerular filtration rate (eGFR) were significantly associated with UA levels in both males and females. Hyperuricemia and increase in UA quartile were significantly associated with decreased forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in females after adjustment for age, income, region, education, marital status, alcohol consumption, smoking, BMI, MAP, HbA1c, and eGFR. There was no significant association between UA levels and lung function in males. After additional adjustment for respiratory disease including pulmonary tuberculosis, asthma, and lung cancer, the association between hyperuricemia and decreased FEV1 and FVC in females was revealed. Conclusions: Hyperuricemia was associated with decreased FVE1 and FVC in the female general population. MDPI 2021-09-10 /pmc/articles/PMC8465554/ /pubmed/34577876 http://dx.doi.org/10.3390/medicina57090953 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jeong, Hyemin
Baek, Sun-Young
Kim, Seon-Woo
Park, Eun-Jung
Kim, Hyungjin
Lee, Jaejoon
Jeon, Chan-Hong
Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title_full Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title_fullStr Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title_full_unstemmed Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title_short Gender-Specific Association of Serum Uric Acid and Pulmonary Function: Data from the Korea National Health and Nutrition Examination Survey
title_sort gender-specific association of serum uric acid and pulmonary function: data from the korea national health and nutrition examination survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465554/
https://www.ncbi.nlm.nih.gov/pubmed/34577876
http://dx.doi.org/10.3390/medicina57090953
work_keys_str_mv AT jeonghyemin genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT baeksunyoung genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT kimseonwoo genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT parkeunjung genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT kimhyungjin genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT leejaejoon genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey
AT jeonchanhong genderspecificassociationofserumuricacidandpulmonaryfunctiondatafromthekoreanationalhealthandnutritionexaminationsurvey