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Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp.
Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amid...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465582/ https://www.ncbi.nlm.nih.gov/pubmed/34564183 http://dx.doi.org/10.3390/md19090521 |
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author | Kim, Hiyoung Lee, Tae Gu Yang, Inho Wang, Weihong Chin, Jungwook Lee, Jusung Rho, Boon Jo Choi, Hyukjae Nam, Sang-Jip Hahn, Dongyup Kang, Heonjoong |
author_facet | Kim, Hiyoung Lee, Tae Gu Yang, Inho Wang, Weihong Chin, Jungwook Lee, Jusung Rho, Boon Jo Choi, Hyukjae Nam, Sang-Jip Hahn, Dongyup Kang, Heonjoong |
author_sort | Kim, Hiyoung |
collection | PubMed |
description | Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1–3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 μg/mL). |
format | Online Article Text |
id | pubmed-8465582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84655822021-09-27 Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. Kim, Hiyoung Lee, Tae Gu Yang, Inho Wang, Weihong Chin, Jungwook Lee, Jusung Rho, Boon Jo Choi, Hyukjae Nam, Sang-Jip Hahn, Dongyup Kang, Heonjoong Mar Drugs Article Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1–3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 μg/mL). MDPI 2021-09-16 /pmc/articles/PMC8465582/ /pubmed/34564183 http://dx.doi.org/10.3390/md19090521 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Hiyoung Lee, Tae Gu Yang, Inho Wang, Weihong Chin, Jungwook Lee, Jusung Rho, Boon Jo Choi, Hyukjae Nam, Sang-Jip Hahn, Dongyup Kang, Heonjoong Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title | Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title_full | Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title_fullStr | Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title_full_unstemmed | Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title_short | Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp. |
title_sort | antibacterial bicyclic fatty acids from a korean colonial tunicate didemnum sp. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465582/ https://www.ncbi.nlm.nih.gov/pubmed/34564183 http://dx.doi.org/10.3390/md19090521 |
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