Modeling Notch-Induced Tumor Cell Survival in the Drosophila Ovary Identifies Cellular and Transcriptional Response to Nuclear NICD Accumulation

Notch is a conserved developmental signaling pathway that is dysregulated in many cancer types, most often through constitutive activation. Tumor cells with nuclear accumulation of the active Notch receptor, NICD, generally exhibit enhanced survival while patients experience poorer outcomes. To unde...

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Detalles Bibliográficos
Autores principales: Jevitt, Allison, Huang, Yi-Chun, Zhang, Su-Mei, Chatterjee, Deeptiman, Wang, Xian-Feng, Xie, Geng-Qiang, Deng, Wu-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465586/
https://www.ncbi.nlm.nih.gov/pubmed/34571871
http://dx.doi.org/10.3390/cells10092222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465586/
https://www.ncbi.nlm.nih.gov/pubmed/34571871
http://dx.doi.org/10.3390/cells10092222

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