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Chromatin Organization and Function in Drosophila

Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribu...

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Autores principales: Llorens-Giralt, Palmira, Camilleri-Robles, Carlos, Corominas, Montserrat, Climent-Cantó, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465611/
https://www.ncbi.nlm.nih.gov/pubmed/34572010
http://dx.doi.org/10.3390/cells10092362
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author Llorens-Giralt, Palmira
Camilleri-Robles, Carlos
Corominas, Montserrat
Climent-Cantó, Paula
author_facet Llorens-Giralt, Palmira
Camilleri-Robles, Carlos
Corominas, Montserrat
Climent-Cantó, Paula
author_sort Llorens-Giralt, Palmira
collection PubMed
description Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribution and folding of chromosomes within the nucleus is critical for understanding the role of chromatin topology in genome function. Primarily focusing on the regulation of gene expression, we review here how the genome of Drosophila melanogaster is organized into the cell nucleus, from small scale histone–DNA interactions to chromosome and lamina interactions in the nuclear space.
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spelling pubmed-84656112021-09-27 Chromatin Organization and Function in Drosophila Llorens-Giralt, Palmira Camilleri-Robles, Carlos Corominas, Montserrat Climent-Cantó, Paula Cells Review Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribution and folding of chromosomes within the nucleus is critical for understanding the role of chromatin topology in genome function. Primarily focusing on the regulation of gene expression, we review here how the genome of Drosophila melanogaster is organized into the cell nucleus, from small scale histone–DNA interactions to chromosome and lamina interactions in the nuclear space. MDPI 2021-09-08 /pmc/articles/PMC8465611/ /pubmed/34572010 http://dx.doi.org/10.3390/cells10092362 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Llorens-Giralt, Palmira
Camilleri-Robles, Carlos
Corominas, Montserrat
Climent-Cantó, Paula
Chromatin Organization and Function in Drosophila
title Chromatin Organization and Function in Drosophila
title_full Chromatin Organization and Function in Drosophila
title_fullStr Chromatin Organization and Function in Drosophila
title_full_unstemmed Chromatin Organization and Function in Drosophila
title_short Chromatin Organization and Function in Drosophila
title_sort chromatin organization and function in drosophila
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465611/
https://www.ncbi.nlm.nih.gov/pubmed/34572010
http://dx.doi.org/10.3390/cells10092362
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