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Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care
Introduction: Real-world data indicate disparities in biologic access across Europe. Objectives: To describe the national structure of PsA care in Poland, with a particular focus on the population of inadequate responders (IRs) and difficulties associated with biologic therapy access. Methods: A poo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465653/ https://www.ncbi.nlm.nih.gov/pubmed/34575217 http://dx.doi.org/10.3390/jcm10184106 |
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author | Batko, Bogdan Kucharz, Eugeniusz Stajszczyk, Marcin Brzosko, Marek Samborski, Włodzimierz Żuber, Zbigniew |
author_facet | Batko, Bogdan Kucharz, Eugeniusz Stajszczyk, Marcin Brzosko, Marek Samborski, Włodzimierz Żuber, Zbigniew |
author_sort | Batko, Bogdan |
collection | PubMed |
description | Introduction: Real-world data indicate disparities in biologic access across Europe. Objectives: To describe the national structure of PsA care in Poland, with a particular focus on the population of inadequate responders (IRs) and difficulties associated with biologic therapy access. Methods: A pool of rheumatologic and dermatologic care centers was created based on National Health Fund contract lists (n = 841), from which 29 rheumatologic and 10 dermatologic centers were sampled randomly and successfully met the inclusion criterium. Additionally, 33 tertiary care centers were recruited. For successful center recruitment, one provider had to recruit at least one patient that met the criteria for one of the four pre-defined clinical subgroups, in which all patients had to have active PsA and IR status to at least 2 conventional synthetic disease-modifying drugs (csDMARDs). Self-assessment questionnaires were distributed among physicians and their patients. Results: Barriers to biologic DMARD (bDMARD) treatment are complex and include stringency of reimbursement criteria, health care system, logistic/organizational, and personal choice factors. For patients who are currently bDMARD users, the median waiting time from the visit, at which the reimbursement procedure was initiated, to the first day of bDMARD admission was 9 weeks (range 2–212; 32% < 4 weeks, 29% 5–12 weeks, 26% 13–28 weeks, 13% with >28 weeks delay). Out of all inadequate responder groups, bDMARD users are the only group with “good” therapeutic situation and satisfaction with therapy. Patient satisfaction with therapy is not always concordant with physician assessment of therapeutic status. Conclusions: Despite the fact that over a decade has passed since the introduction of biologic agents, in medium welfare countries such as Poland, considerable healthcare system barriers to biologic access are present. Out of different IR populations, patient satisfaction with treatment is often discordant with physician assessment of disease status. |
format | Online Article Text |
id | pubmed-8465653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84656532021-09-27 Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care Batko, Bogdan Kucharz, Eugeniusz Stajszczyk, Marcin Brzosko, Marek Samborski, Włodzimierz Żuber, Zbigniew J Clin Med Article Introduction: Real-world data indicate disparities in biologic access across Europe. Objectives: To describe the national structure of PsA care in Poland, with a particular focus on the population of inadequate responders (IRs) and difficulties associated with biologic therapy access. Methods: A pool of rheumatologic and dermatologic care centers was created based on National Health Fund contract lists (n = 841), from which 29 rheumatologic and 10 dermatologic centers were sampled randomly and successfully met the inclusion criterium. Additionally, 33 tertiary care centers were recruited. For successful center recruitment, one provider had to recruit at least one patient that met the criteria for one of the four pre-defined clinical subgroups, in which all patients had to have active PsA and IR status to at least 2 conventional synthetic disease-modifying drugs (csDMARDs). Self-assessment questionnaires were distributed among physicians and their patients. Results: Barriers to biologic DMARD (bDMARD) treatment are complex and include stringency of reimbursement criteria, health care system, logistic/organizational, and personal choice factors. For patients who are currently bDMARD users, the median waiting time from the visit, at which the reimbursement procedure was initiated, to the first day of bDMARD admission was 9 weeks (range 2–212; 32% < 4 weeks, 29% 5–12 weeks, 26% 13–28 weeks, 13% with >28 weeks delay). Out of all inadequate responder groups, bDMARD users are the only group with “good” therapeutic situation and satisfaction with therapy. Patient satisfaction with therapy is not always concordant with physician assessment of therapeutic status. Conclusions: Despite the fact that over a decade has passed since the introduction of biologic agents, in medium welfare countries such as Poland, considerable healthcare system barriers to biologic access are present. Out of different IR populations, patient satisfaction with treatment is often discordant with physician assessment of disease status. MDPI 2021-09-11 /pmc/articles/PMC8465653/ /pubmed/34575217 http://dx.doi.org/10.3390/jcm10184106 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Batko, Bogdan Kucharz, Eugeniusz Stajszczyk, Marcin Brzosko, Marek Samborski, Włodzimierz Żuber, Zbigniew Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title | Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title_full | Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title_fullStr | Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title_full_unstemmed | Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title_short | Real-World Data from a Multi-Center Study: Insights to Psoriatic Arthritis Care |
title_sort | real-world data from a multi-center study: insights to psoriatic arthritis care |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465653/ https://www.ncbi.nlm.nih.gov/pubmed/34575217 http://dx.doi.org/10.3390/jcm10184106 |
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