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Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study

Backgroundand Objectives: COVID-19 is a novel infectious disease caused by a single-stranded RNA coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to conduct a nationwide multicenter study to determine the characteristics and the clinical prognostic outcome of...

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Autores principales: Al Mutair, Abbas, Elhazmi, Alyaa, Alhumaid, Saad, Ahmad, Gasmelseed Y., Rabaan, Ali A., Alghdeer, Mohammed A., Chagla, Hiba, Tirupathi, Raghavendra, Sharma, Amit, Dhama, Kuldeep, Alsalman, Khulud, Alalawi, Zainab, Aljofan, Ziyad, Al Mutairi, Alya, Alomari, Mohammed, Awad, Mansour, Al-Omari, Awad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465663/
https://www.ncbi.nlm.nih.gov/pubmed/34577801
http://dx.doi.org/10.3390/medicina57090878
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author Al Mutair, Abbas
Elhazmi, Alyaa
Alhumaid, Saad
Ahmad, Gasmelseed Y.
Rabaan, Ali A.
Alghdeer, Mohammed A.
Chagla, Hiba
Tirupathi, Raghavendra
Sharma, Amit
Dhama, Kuldeep
Alsalman, Khulud
Alalawi, Zainab
Aljofan, Ziyad
Al Mutairi, Alya
Alomari, Mohammed
Awad, Mansour
Al-Omari, Awad
author_facet Al Mutair, Abbas
Elhazmi, Alyaa
Alhumaid, Saad
Ahmad, Gasmelseed Y.
Rabaan, Ali A.
Alghdeer, Mohammed A.
Chagla, Hiba
Tirupathi, Raghavendra
Sharma, Amit
Dhama, Kuldeep
Alsalman, Khulud
Alalawi, Zainab
Aljofan, Ziyad
Al Mutairi, Alya
Alomari, Mohammed
Awad, Mansour
Al-Omari, Awad
author_sort Al Mutair, Abbas
collection PubMed
description Backgroundand Objectives: COVID-19 is a novel infectious disease caused by a single-stranded RNA coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to conduct a nationwide multicenter study to determine the characteristics and the clinical prognostic outcome of critically ill COVID-19 patients admitted to intensive care units (ICUs). Materials and Methods: This is a nationwide cohort retrospective study conducted in twenty Saudi hospitals. Results: An analysis of 1470 critically ill COVID-19 patients demonstrated that the majority of patients were male with a mean age of 55.9 ± 15.1 years. Most of our patients presented with a shortness of breath (SOB) (81.3%), followed by a fever (73.7%) and a cough (65.1%). Diabetes and hypertension were the most common comorbidities in the study (52.4% and 46.0%, respectively). Multiple complications were observed substantially more among non-survivors. The length and frequency of mechanical ventilation use were significantly greater (83%) in the non-survivors compared with the survivors (31%). The mean Sequential Organ Failure Assessment (SOFA) score was 6 ± 5. The overall mortality rate of the cohort associated with patients that had diabetes, hypertension and ischemic heart disease was 41.8%. Conclusion: Age; a pre-existing medical history of hypertension, diabetes and ischemic heart disease; smoking cigarettes; a BMI ≥ 29; a long mechanical ventilation and ICU stay; the need of ventilatory support; a high SOFA score; fungal co-infections and extracorporeal membrane oxygenation (ECMO) use were key clinical characteristics that predicted a high mortality in our population.
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spelling pubmed-84656632021-09-27 Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study Al Mutair, Abbas Elhazmi, Alyaa Alhumaid, Saad Ahmad, Gasmelseed Y. Rabaan, Ali A. Alghdeer, Mohammed A. Chagla, Hiba Tirupathi, Raghavendra Sharma, Amit Dhama, Kuldeep Alsalman, Khulud Alalawi, Zainab Aljofan, Ziyad Al Mutairi, Alya Alomari, Mohammed Awad, Mansour Al-Omari, Awad Medicina (Kaunas) Article Backgroundand Objectives: COVID-19 is a novel infectious disease caused by a single-stranded RNA coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aimed to conduct a nationwide multicenter study to determine the characteristics and the clinical prognostic outcome of critically ill COVID-19 patients admitted to intensive care units (ICUs). Materials and Methods: This is a nationwide cohort retrospective study conducted in twenty Saudi hospitals. Results: An analysis of 1470 critically ill COVID-19 patients demonstrated that the majority of patients were male with a mean age of 55.9 ± 15.1 years. Most of our patients presented with a shortness of breath (SOB) (81.3%), followed by a fever (73.7%) and a cough (65.1%). Diabetes and hypertension were the most common comorbidities in the study (52.4% and 46.0%, respectively). Multiple complications were observed substantially more among non-survivors. The length and frequency of mechanical ventilation use were significantly greater (83%) in the non-survivors compared with the survivors (31%). The mean Sequential Organ Failure Assessment (SOFA) score was 6 ± 5. The overall mortality rate of the cohort associated with patients that had diabetes, hypertension and ischemic heart disease was 41.8%. Conclusion: Age; a pre-existing medical history of hypertension, diabetes and ischemic heart disease; smoking cigarettes; a BMI ≥ 29; a long mechanical ventilation and ICU stay; the need of ventilatory support; a high SOFA score; fungal co-infections and extracorporeal membrane oxygenation (ECMO) use were key clinical characteristics that predicted a high mortality in our population. MDPI 2021-08-26 /pmc/articles/PMC8465663/ /pubmed/34577801 http://dx.doi.org/10.3390/medicina57090878 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al Mutair, Abbas
Elhazmi, Alyaa
Alhumaid, Saad
Ahmad, Gasmelseed Y.
Rabaan, Ali A.
Alghdeer, Mohammed A.
Chagla, Hiba
Tirupathi, Raghavendra
Sharma, Amit
Dhama, Kuldeep
Alsalman, Khulud
Alalawi, Zainab
Aljofan, Ziyad
Al Mutairi, Alya
Alomari, Mohammed
Awad, Mansour
Al-Omari, Awad
Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title_full Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title_fullStr Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title_full_unstemmed Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title_short Examining the Clinical Prognosis of Critically Ill Patients with COVID-19 Admitted to Intensive Care Units: A Nationwide Saudi Study
title_sort examining the clinical prognosis of critically ill patients with covid-19 admitted to intensive care units: a nationwide saudi study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465663/
https://www.ncbi.nlm.nih.gov/pubmed/34577801
http://dx.doi.org/10.3390/medicina57090878
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