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Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?

BACKGROUND: Extensive literature has shown an association of Adverse Childhood Experiences (ACEs) with adverse health outcomes; however, its ability to predict events or stratify risks is less known. Individuals with mental illness and ACE exposure have been shown to visit emergency departments (ED)...

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Autores principales: Bhattarai, Asmita, Dimitropoulos, Gina, Marriott, Brian, Paget, Jaime, Bulloch, Andrew G. M., Tough, Suzanne C., Patten, Scott B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465692/
https://www.ncbi.nlm.nih.gov/pubmed/34563122
http://dx.doi.org/10.1186/s12874-021-01392-w
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author Bhattarai, Asmita
Dimitropoulos, Gina
Marriott, Brian
Paget, Jaime
Bulloch, Andrew G. M.
Tough, Suzanne C.
Patten, Scott B.
author_facet Bhattarai, Asmita
Dimitropoulos, Gina
Marriott, Brian
Paget, Jaime
Bulloch, Andrew G. M.
Tough, Suzanne C.
Patten, Scott B.
author_sort Bhattarai, Asmita
collection PubMed
description BACKGROUND: Extensive literature has shown an association of Adverse Childhood Experiences (ACEs) with adverse health outcomes; however, its ability to predict events or stratify risks is less known. Individuals with mental illness and ACE exposure have been shown to visit emergency departments (ED) more often than those in the general population. This study thus examined the ability of the ACEs checklist to predict ED visits within the subsequent year among children and adolescents presenting to mental health clinics with pre-existing mental health issues. METHODS: The study analyzed linked data (n = 6100) from two databases provided by Alberta Health Services (AHS). The Regional Access and Intake System (RAIS 2016–2018) database provided data on the predictors (ACE items, age, sex, residence, mental health program type, and primary diagnosis) regarding children and adolescents (aged 0–17 years) accessing addiction and mental health services within Calgary Zone, and the National Ambulatory Care Reporting System (NACRS 2016–2019) database provided data on ED visits. A 25% random sample of the data was reserved for validation purposes. Two Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression models, each employing a different method to tune the shrinkage parameter lambda (namely cross-validated and adaptive) and performing 10-fold cross-validation for a set of 100 lambdas in each model were examined. RESULTS: The adaptive LASSO model had a slightly better fit in the validation dataset than the cross-validated model; however, it still demonstrated poor discrimination (AUC 0.60, sensitivity 37.8%, PPV 49.6%) and poor calibration (over-triaged in low-risk and under-triaged in high-risk subgroups). The model’s poor performance was evident from an out-of-sample deviance ratio of − 0.044. CONCLUSION: The ACEs checklist did not perform well in predicting ED visits among children and adolescents with existing mental health concerns. The diverse causes of ED visits may have hindered accurate predictions, requiring more advanced statistical procedures. Future studies exploring other machine learning approaches and including a more extensive set of childhood adversities and other important predictors may produce better predictions. Furthermore, despite highly significant associations being observed, ACEs may not be deterministic in predicting health-related events at the individual level, such as general ED use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12874-021-01392-w.
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spelling pubmed-84656922021-09-27 Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents? Bhattarai, Asmita Dimitropoulos, Gina Marriott, Brian Paget, Jaime Bulloch, Andrew G. M. Tough, Suzanne C. Patten, Scott B. BMC Med Res Methodol Research BACKGROUND: Extensive literature has shown an association of Adverse Childhood Experiences (ACEs) with adverse health outcomes; however, its ability to predict events or stratify risks is less known. Individuals with mental illness and ACE exposure have been shown to visit emergency departments (ED) more often than those in the general population. This study thus examined the ability of the ACEs checklist to predict ED visits within the subsequent year among children and adolescents presenting to mental health clinics with pre-existing mental health issues. METHODS: The study analyzed linked data (n = 6100) from two databases provided by Alberta Health Services (AHS). The Regional Access and Intake System (RAIS 2016–2018) database provided data on the predictors (ACE items, age, sex, residence, mental health program type, and primary diagnosis) regarding children and adolescents (aged 0–17 years) accessing addiction and mental health services within Calgary Zone, and the National Ambulatory Care Reporting System (NACRS 2016–2019) database provided data on ED visits. A 25% random sample of the data was reserved for validation purposes. Two Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression models, each employing a different method to tune the shrinkage parameter lambda (namely cross-validated and adaptive) and performing 10-fold cross-validation for a set of 100 lambdas in each model were examined. RESULTS: The adaptive LASSO model had a slightly better fit in the validation dataset than the cross-validated model; however, it still demonstrated poor discrimination (AUC 0.60, sensitivity 37.8%, PPV 49.6%) and poor calibration (over-triaged in low-risk and under-triaged in high-risk subgroups). The model’s poor performance was evident from an out-of-sample deviance ratio of − 0.044. CONCLUSION: The ACEs checklist did not perform well in predicting ED visits among children and adolescents with existing mental health concerns. The diverse causes of ED visits may have hindered accurate predictions, requiring more advanced statistical procedures. Future studies exploring other machine learning approaches and including a more extensive set of childhood adversities and other important predictors may produce better predictions. Furthermore, despite highly significant associations being observed, ACEs may not be deterministic in predicting health-related events at the individual level, such as general ED use. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12874-021-01392-w. BioMed Central 2021-09-25 /pmc/articles/PMC8465692/ /pubmed/34563122 http://dx.doi.org/10.1186/s12874-021-01392-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Bhattarai, Asmita
Dimitropoulos, Gina
Marriott, Brian
Paget, Jaime
Bulloch, Andrew G. M.
Tough, Suzanne C.
Patten, Scott B.
Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title_full Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title_fullStr Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title_full_unstemmed Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title_short Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents?
title_sort can the adverse childhood experiences (aces) checklist be utilized to predict emergency department visits among children and adolescents?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465692/
https://www.ncbi.nlm.nih.gov/pubmed/34563122
http://dx.doi.org/10.1186/s12874-021-01392-w
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