Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications

Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity,...

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Detalles Bibliográficos
Autores principales: Fatima, Atiya, Ahmad, Md. Wasi, Al Saidi, Abdullah Khamis Ali, Choudhury, Arup, Chang, Yongmin, Lee, Gang Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465722/
https://www.ncbi.nlm.nih.gov/pubmed/34578765
http://dx.doi.org/10.3390/nano11092449
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author Fatima, Atiya
Ahmad, Md. Wasi
Al Saidi, Abdullah Khamis Ali
Choudhury, Arup
Chang, Yongmin
Lee, Gang Ho
author_facet Fatima, Atiya
Ahmad, Md. Wasi
Al Saidi, Abdullah Khamis Ali
Choudhury, Arup
Chang, Yongmin
Lee, Gang Ho
author_sort Fatima, Atiya
collection PubMed
description Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly.
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spelling pubmed-84657222021-09-27 Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications Fatima, Atiya Ahmad, Md. Wasi Al Saidi, Abdullah Khamis Ali Choudhury, Arup Chang, Yongmin Lee, Gang Ho Nanomaterials (Basel) Review Gadolinium (Gd) based contrast agents (CAs) (Gd-CAs) represent one of the most advanced developments in the application of Gd for magnetic resonance imaging (MRI). Current challenges with existing CAs generated an urgent requirement to develop multimodal CAs with good biocompatibility, low toxicity, and prolonged circulation time. This review discussed the Gd-CAs used in bioimaging applications, addressing their advantages and limitations. Future research is required to establish the safety, efficacy and theragnostic capabilities of Gd-CAs. Nevertheless, these Gd-CAs offer extraordinary potential as imaging CAs and promise to benefit bioimaging applications significantly. MDPI 2021-09-20 /pmc/articles/PMC8465722/ /pubmed/34578765 http://dx.doi.org/10.3390/nano11092449 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fatima, Atiya
Ahmad, Md. Wasi
Al Saidi, Abdullah Khamis Ali
Choudhury, Arup
Chang, Yongmin
Lee, Gang Ho
Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title_full Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title_fullStr Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title_full_unstemmed Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title_short Recent Advances in Gadolinium Based Contrast Agents for Bioimaging Applications
title_sort recent advances in gadolinium based contrast agents for bioimaging applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465722/
https://www.ncbi.nlm.nih.gov/pubmed/34578765
http://dx.doi.org/10.3390/nano11092449
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