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The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database
BACKGROUND: Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer patients. METHODS: Retrieving esophageal can...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465786/ https://www.ncbi.nlm.nih.gov/pubmed/34563149 http://dx.doi.org/10.1186/s12885-021-08802-8 |
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author | Cheng, Shizhao Yang, Lei Dai, Xin Wang, Jing Han, Xingpeng |
author_facet | Cheng, Shizhao Yang, Lei Dai, Xin Wang, Jing Han, Xingpeng |
author_sort | Cheng, Shizhao |
collection | PubMed |
description | BACKGROUND: Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer patients. METHODS: Retrieving esophageal cancer patients diagnosed between 2010 and 2018 from the SEER database, univariable and multivariable logistic and cox regression models were used to investigate the risk factors for brain metastases development and prognosis, respectively. The brain metastases predicting nomogram was constructed, evaluated and validated. The overall survival (OS) of patients with brain metastases was analyzed by Kaplan–Meier method. RESULTS: A total of 34,107 eligible esophageal cancer patients were included and 618 of them were diagnosed with brain metastases (1.8%). The median survival of the brain metastatic esophageal cancer patients was 5 (95% CI: 5–7) months. The presence of bone metastases and lung metastases were the homogeneously associated factors for the development and prognosis of brain metastases in esophageal cancer patients. Patients younger than 65 years, American Indian/Alaska Native race (vs. White), overlapping lesion (vs. Upper third), esophageal adenocarcinoma histology subtype, higher N stage, and liver metastases were positively associated with brain metastases occurrence. The calibration curve, ROC curve, and C-index exhibited good performance of the nomogram for predicting brain metastases. CONCLUSIONS: Homogeneous and heterogeneous factors were found for the development and prognosis of brain metastases in esophageal cancer patients. The nomogram had good calibration and discrimination for predicting brain metastases. |
format | Online Article Text |
id | pubmed-8465786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-84657862021-09-27 The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database Cheng, Shizhao Yang, Lei Dai, Xin Wang, Jing Han, Xingpeng BMC Cancer Research BACKGROUND: Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal cancer patients. METHODS: Retrieving esophageal cancer patients diagnosed between 2010 and 2018 from the SEER database, univariable and multivariable logistic and cox regression models were used to investigate the risk factors for brain metastases development and prognosis, respectively. The brain metastases predicting nomogram was constructed, evaluated and validated. The overall survival (OS) of patients with brain metastases was analyzed by Kaplan–Meier method. RESULTS: A total of 34,107 eligible esophageal cancer patients were included and 618 of them were diagnosed with brain metastases (1.8%). The median survival of the brain metastatic esophageal cancer patients was 5 (95% CI: 5–7) months. The presence of bone metastases and lung metastases were the homogeneously associated factors for the development and prognosis of brain metastases in esophageal cancer patients. Patients younger than 65 years, American Indian/Alaska Native race (vs. White), overlapping lesion (vs. Upper third), esophageal adenocarcinoma histology subtype, higher N stage, and liver metastases were positively associated with brain metastases occurrence. The calibration curve, ROC curve, and C-index exhibited good performance of the nomogram for predicting brain metastases. CONCLUSIONS: Homogeneous and heterogeneous factors were found for the development and prognosis of brain metastases in esophageal cancer patients. The nomogram had good calibration and discrimination for predicting brain metastases. BioMed Central 2021-09-26 /pmc/articles/PMC8465786/ /pubmed/34563149 http://dx.doi.org/10.1186/s12885-021-08802-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Cheng, Shizhao Yang, Lei Dai, Xin Wang, Jing Han, Xingpeng The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title | The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title_full | The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title_fullStr | The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title_full_unstemmed | The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title_short | The risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the SEER database |
title_sort | risk and prognostic factors for brain metastases in esophageal cancer patients: an analysis of the seer database |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465786/ https://www.ncbi.nlm.nih.gov/pubmed/34563149 http://dx.doi.org/10.1186/s12885-021-08802-8 |
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