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The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease

The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current...

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Detalles Bibliográficos
Autores principales: Stojek, Magdalena, Jabłońska, Anna, Adrych, Krystian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465860/
https://www.ncbi.nlm.nih.gov/pubmed/34575166
http://dx.doi.org/10.3390/jcm10184055
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author Stojek, Magdalena
Jabłońska, Anna
Adrych, Krystian
author_facet Stojek, Magdalena
Jabłońska, Anna
Adrych, Krystian
author_sort Stojek, Magdalena
collection PubMed
description The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice.
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spelling pubmed-84658602021-09-27 The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease Stojek, Magdalena Jabłońska, Anna Adrych, Krystian J Clin Med Review The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice. MDPI 2021-09-08 /pmc/articles/PMC8465860/ /pubmed/34575166 http://dx.doi.org/10.3390/jcm10184055 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stojek, Magdalena
Jabłońska, Anna
Adrych, Krystian
The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title_full The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title_fullStr The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title_full_unstemmed The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title_short The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
title_sort role of fecal microbiota transplantation in the treatment of inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465860/
https://www.ncbi.nlm.nih.gov/pubmed/34575166
http://dx.doi.org/10.3390/jcm10184055
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