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The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease
The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465860/ https://www.ncbi.nlm.nih.gov/pubmed/34575166 http://dx.doi.org/10.3390/jcm10184055 |
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author | Stojek, Magdalena Jabłońska, Anna Adrych, Krystian |
author_facet | Stojek, Magdalena Jabłońska, Anna Adrych, Krystian |
author_sort | Stojek, Magdalena |
collection | PubMed |
description | The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice. |
format | Online Article Text |
id | pubmed-8465860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84658602021-09-27 The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease Stojek, Magdalena Jabłońska, Anna Adrych, Krystian J Clin Med Review The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice. MDPI 2021-09-08 /pmc/articles/PMC8465860/ /pubmed/34575166 http://dx.doi.org/10.3390/jcm10184055 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Stojek, Magdalena Jabłońska, Anna Adrych, Krystian The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title_full | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title_fullStr | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title_full_unstemmed | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title_short | The Role of Fecal Microbiota Transplantation in the Treatment of Inflammatory Bowel Disease |
title_sort | role of fecal microbiota transplantation in the treatment of inflammatory bowel disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465860/ https://www.ncbi.nlm.nih.gov/pubmed/34575166 http://dx.doi.org/10.3390/jcm10184055 |
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