Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic and Inhibitor

Neuronal miRNA dysregulation may have a role in the pathophysiology of Alzheimer’s disease (AD). miRNA(miR)-124 is largely abundant and a critical player in many neuronal functions. However, the lack of models reliably recapitulating AD pathophysiology hampers our understanding of miR-124’s role in...

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Detalles Bibliográficos
Autores principales: Garcia, Gonçalo, Pinto, Sara, Cunha, Mar, Fernandes, Adelaide, Koistinaho, Jari, Brites, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465877/
https://www.ncbi.nlm.nih.gov/pubmed/34572073
http://dx.doi.org/10.3390/cells10092424

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