Cargando…

Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts

Propionibacterium acnes, newly reclassified as Cutibacterium acnes, is an anaerobic Gram-positive bacterium causing acne, found mainly on the skin. In addition, P. acnes is responsible for inflammation of the gums (gingivitis) and blood vessels, consequently leading to various diseases in the human...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Hyoung-An, Ahn, Sang-Oh, Lim, Ho-Dong, Kim, Geun-Joong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465884/
https://www.ncbi.nlm.nih.gov/pubmed/34572674
http://dx.doi.org/10.3390/antibiotics10091092
_version_ 1784572990355144704
author Choi, Hyoung-An
Ahn, Sang-Oh
Lim, Ho-Dong
Kim, Geun-Joong
author_facet Choi, Hyoung-An
Ahn, Sang-Oh
Lim, Ho-Dong
Kim, Geun-Joong
author_sort Choi, Hyoung-An
collection PubMed
description Propionibacterium acnes, newly reclassified as Cutibacterium acnes, is an anaerobic Gram-positive bacterium causing acne, found mainly on the skin. In addition, P. acnes is responsible for inflammation of the gums (gingivitis) and blood vessels, consequently leading to various diseases in the human body. In recent years, the evolution of microorganisms, such as P. acnes, that have become resistant to many commercial antibiotics due to the widespread use of antimicrobial drugs in the treatment of infectious diseases has emerged as a major clinical problem. We here analyzed the potential use of 37 medicinal plant extracts as plausible candidates for treating P. acnes, in terms of total phenolic and flavonoid contents, antioxidants scavenging and antimicrobial activity. Consequently, methanol extracts from 14 medicinal plants showed promising antimicrobial activities against P. acnes. In particular, as the extracts from Chrysosplenium flagelliferum F. and Thuja orientalis L. exhibited distinct antimicrobial activities in both the broth dilution and disc diffusion assay, they could be effectively used as active ingredients for preventing or treating inflammatory periodontal diseases, such as periodontitis.
format Online
Article
Text
id pubmed-8465884
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84658842021-09-27 Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts Choi, Hyoung-An Ahn, Sang-Oh Lim, Ho-Dong Kim, Geun-Joong Antibiotics (Basel) Article Propionibacterium acnes, newly reclassified as Cutibacterium acnes, is an anaerobic Gram-positive bacterium causing acne, found mainly on the skin. In addition, P. acnes is responsible for inflammation of the gums (gingivitis) and blood vessels, consequently leading to various diseases in the human body. In recent years, the evolution of microorganisms, such as P. acnes, that have become resistant to many commercial antibiotics due to the widespread use of antimicrobial drugs in the treatment of infectious diseases has emerged as a major clinical problem. We here analyzed the potential use of 37 medicinal plant extracts as plausible candidates for treating P. acnes, in terms of total phenolic and flavonoid contents, antioxidants scavenging and antimicrobial activity. Consequently, methanol extracts from 14 medicinal plants showed promising antimicrobial activities against P. acnes. In particular, as the extracts from Chrysosplenium flagelliferum F. and Thuja orientalis L. exhibited distinct antimicrobial activities in both the broth dilution and disc diffusion assay, they could be effectively used as active ingredients for preventing or treating inflammatory periodontal diseases, such as periodontitis. MDPI 2021-09-09 /pmc/articles/PMC8465884/ /pubmed/34572674 http://dx.doi.org/10.3390/antibiotics10091092 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Hyoung-An
Ahn, Sang-Oh
Lim, Ho-Dong
Kim, Geun-Joong
Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title_full Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title_fullStr Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title_full_unstemmed Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title_short Growth Suppression of a Gingivitis and Skin Pathogen Cutibacterium (Propionibacterium) acnes by Medicinal Plant Extracts
title_sort growth suppression of a gingivitis and skin pathogen cutibacterium (propionibacterium) acnes by medicinal plant extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465884/
https://www.ncbi.nlm.nih.gov/pubmed/34572674
http://dx.doi.org/10.3390/antibiotics10091092
work_keys_str_mv AT choihyoungan growthsuppressionofagingivitisandskinpathogencutibacteriumpropionibacteriumacnesbymedicinalplantextracts
AT ahnsangoh growthsuppressionofagingivitisandskinpathogencutibacteriumpropionibacteriumacnesbymedicinalplantextracts
AT limhodong growthsuppressionofagingivitisandskinpathogencutibacteriumpropionibacteriumacnesbymedicinalplantextracts
AT kimgeunjoong growthsuppressionofagingivitisandskinpathogencutibacteriumpropionibacteriumacnesbymedicinalplantextracts