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Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465911/ https://www.ncbi.nlm.nih.gov/pubmed/34573295 http://dx.doi.org/10.3390/genes12091313 |
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author | Tarnowski, Maciej Kopytko, Patrycja Piotrowska, Katarzyna |
author_facet | Tarnowski, Maciej Kopytko, Patrycja Piotrowska, Katarzyna |
author_sort | Tarnowski, Maciej |
collection | PubMed |
description | Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect. |
format | Online Article Text |
id | pubmed-8465911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84659112021-09-27 Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity Tarnowski, Maciej Kopytko, Patrycja Piotrowska, Katarzyna Genes (Basel) Review Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect. MDPI 2021-08-25 /pmc/articles/PMC8465911/ /pubmed/34573295 http://dx.doi.org/10.3390/genes12091313 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tarnowski, Maciej Kopytko, Patrycja Piotrowska, Katarzyna Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title | Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_full | Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_fullStr | Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_full_unstemmed | Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_short | Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity |
title_sort | epigenetic regulation of inflammatory responses in the context of physical activity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465911/ https://www.ncbi.nlm.nih.gov/pubmed/34573295 http://dx.doi.org/10.3390/genes12091313 |
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