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Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity

Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vit...

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Autores principales: Tarnowski, Maciej, Kopytko, Patrycja, Piotrowska, Katarzyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465911/
https://www.ncbi.nlm.nih.gov/pubmed/34573295
http://dx.doi.org/10.3390/genes12091313
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author Tarnowski, Maciej
Kopytko, Patrycja
Piotrowska, Katarzyna
author_facet Tarnowski, Maciej
Kopytko, Patrycja
Piotrowska, Katarzyna
author_sort Tarnowski, Maciej
collection PubMed
description Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect.
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spelling pubmed-84659112021-09-27 Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity Tarnowski, Maciej Kopytko, Patrycja Piotrowska, Katarzyna Genes (Basel) Review Epigenetic modifications occur in response to environmental changes and play a fundamental role in the regulation of gene expression. PA is found to elicit an inflammatory response, both from the innate and adaptive divisions of the immunological system. The inflammatory reaction is considered a vital trigger of epigenetic changes that in turn modulate inflammatory actions. The tissue responses to PA involve local and general changes. The epigenetic mechanisms involved include: DNA methylation, histone proteins modification and microRNA. All of them affect genetic expression in an inflammatory milieu in physical exercise depending on the magnitude of physiological stress experienced by the exerciser. PA may evoke acute or chronic biochemical and physiological responses and have a positive or negative immunomodulatory effect. MDPI 2021-08-25 /pmc/articles/PMC8465911/ /pubmed/34573295 http://dx.doi.org/10.3390/genes12091313 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tarnowski, Maciej
Kopytko, Patrycja
Piotrowska, Katarzyna
Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title_full Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title_fullStr Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title_full_unstemmed Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title_short Epigenetic Regulation of Inflammatory Responses in the Context of Physical Activity
title_sort epigenetic regulation of inflammatory responses in the context of physical activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465911/
https://www.ncbi.nlm.nih.gov/pubmed/34573295
http://dx.doi.org/10.3390/genes12091313
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