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Advances in ER-Phagy and Its Diseases Relevance
As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including n...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465915/ https://www.ncbi.nlm.nih.gov/pubmed/34571977 http://dx.doi.org/10.3390/cells10092328 |
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author | He, Lingang Qian, Xuehong Cui, Yixian |
author_facet | He, Lingang Qian, Xuehong Cui, Yixian |
author_sort | He, Lingang |
collection | PubMed |
description | As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases. |
format | Online Article Text |
id | pubmed-8465915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84659152021-09-27 Advances in ER-Phagy and Its Diseases Relevance He, Lingang Qian, Xuehong Cui, Yixian Cells Review As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases. MDPI 2021-09-06 /pmc/articles/PMC8465915/ /pubmed/34571977 http://dx.doi.org/10.3390/cells10092328 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review He, Lingang Qian, Xuehong Cui, Yixian Advances in ER-Phagy and Its Diseases Relevance |
title | Advances in ER-Phagy and Its Diseases Relevance |
title_full | Advances in ER-Phagy and Its Diseases Relevance |
title_fullStr | Advances in ER-Phagy and Its Diseases Relevance |
title_full_unstemmed | Advances in ER-Phagy and Its Diseases Relevance |
title_short | Advances in ER-Phagy and Its Diseases Relevance |
title_sort | advances in er-phagy and its diseases relevance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465915/ https://www.ncbi.nlm.nih.gov/pubmed/34571977 http://dx.doi.org/10.3390/cells10092328 |
work_keys_str_mv | AT helingang advancesinerphagyanditsdiseasesrelevance AT qianxuehong advancesinerphagyanditsdiseasesrelevance AT cuiyixian advancesinerphagyanditsdiseasesrelevance |