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Advances in ER-Phagy and Its Diseases Relevance

As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including n...

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Detalles Bibliográficos
Autores principales: He, Lingang, Qian, Xuehong, Cui, Yixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465915/
https://www.ncbi.nlm.nih.gov/pubmed/34571977
http://dx.doi.org/10.3390/cells10092328
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author He, Lingang
Qian, Xuehong
Cui, Yixian
author_facet He, Lingang
Qian, Xuehong
Cui, Yixian
author_sort He, Lingang
collection PubMed
description As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases.
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spelling pubmed-84659152021-09-27 Advances in ER-Phagy and Its Diseases Relevance He, Lingang Qian, Xuehong Cui, Yixian Cells Review As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationship between ER-phagy and human diseases, including neurodegenerative disorders, cancer, and other metabolic diseases has been unveiled by extensive research in recent years. Starting with the catabolic process of ER-phagy and key mediators in this pathway, this paper reviews the advances in the mechanism of ER-phagy and its diseases relevance. We hope to provide some enlightenment for further study on ER-phagy and the development of novel therapeutic strategies for related diseases. MDPI 2021-09-06 /pmc/articles/PMC8465915/ /pubmed/34571977 http://dx.doi.org/10.3390/cells10092328 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Lingang
Qian, Xuehong
Cui, Yixian
Advances in ER-Phagy and Its Diseases Relevance
title Advances in ER-Phagy and Its Diseases Relevance
title_full Advances in ER-Phagy and Its Diseases Relevance
title_fullStr Advances in ER-Phagy and Its Diseases Relevance
title_full_unstemmed Advances in ER-Phagy and Its Diseases Relevance
title_short Advances in ER-Phagy and Its Diseases Relevance
title_sort advances in er-phagy and its diseases relevance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465915/
https://www.ncbi.nlm.nih.gov/pubmed/34571977
http://dx.doi.org/10.3390/cells10092328
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