Cargando…

3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery

Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applic...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Ge, Ahn, Minjun, Cho, Won-Woo, Kim, Byoung-Soo, Cho, Dong-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465948/
https://www.ncbi.nlm.nih.gov/pubmed/34575448
http://dx.doi.org/10.3390/pharmaceutics13091373
_version_ 1784573006622752768
author Gao, Ge
Ahn, Minjun
Cho, Won-Woo
Kim, Byoung-Soo
Cho, Dong-Woo
author_facet Gao, Ge
Ahn, Minjun
Cho, Won-Woo
Kim, Byoung-Soo
Cho, Dong-Woo
author_sort Gao, Ge
collection PubMed
description Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applications, enabling the development of customized drug screening and drug delivery systems for individual patients, breaking away from conventional approaches that primarily rely on transgenic animal experiments and mass production. This review provides an extensive overview of 3D printing research applied to drug screening and drug delivery systems that represent pharmaceutical applications. We classify several elements required by each application for advanced pharmaceutical techniques and briefly describe state-of-the-art 3D printing technology consisting of cells, bioinks, and printing strategies that satisfy requirements. Furthermore, we discuss the limitations of traditional approaches by providing concrete examples of drug screening (organoid, organ-on-a-chip, and tissue/organ equivalent) and drug delivery systems (oral/vaginal/rectal and transdermal/surgical drug delivery), followed by the introduction of recent pharmaceutical investigations using 3D printing-based strategies to overcome these challenges.
format Online
Article
Text
id pubmed-8465948
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-84659482021-09-27 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery Gao, Ge Ahn, Minjun Cho, Won-Woo Kim, Byoung-Soo Cho, Dong-Woo Pharmaceutics Review Advances in three-dimensional (3D) printing techniques and the development of tailored biomaterials have facilitated the precise fabrication of biological components and complex 3D geometrics over the past few decades. Moreover, the notable growth of 3D printing has facilitated pharmaceutical applications, enabling the development of customized drug screening and drug delivery systems for individual patients, breaking away from conventional approaches that primarily rely on transgenic animal experiments and mass production. This review provides an extensive overview of 3D printing research applied to drug screening and drug delivery systems that represent pharmaceutical applications. We classify several elements required by each application for advanced pharmaceutical techniques and briefly describe state-of-the-art 3D printing technology consisting of cells, bioinks, and printing strategies that satisfy requirements. Furthermore, we discuss the limitations of traditional approaches by providing concrete examples of drug screening (organoid, organ-on-a-chip, and tissue/organ equivalent) and drug delivery systems (oral/vaginal/rectal and transdermal/surgical drug delivery), followed by the introduction of recent pharmaceutical investigations using 3D printing-based strategies to overcome these challenges. MDPI 2021-08-31 /pmc/articles/PMC8465948/ /pubmed/34575448 http://dx.doi.org/10.3390/pharmaceutics13091373 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Ge
Ahn, Minjun
Cho, Won-Woo
Kim, Byoung-Soo
Cho, Dong-Woo
3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title_full 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title_fullStr 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title_full_unstemmed 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title_short 3D Printing of Pharmaceutical Application: Drug Screening and Drug Delivery
title_sort 3d printing of pharmaceutical application: drug screening and drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465948/
https://www.ncbi.nlm.nih.gov/pubmed/34575448
http://dx.doi.org/10.3390/pharmaceutics13091373
work_keys_str_mv AT gaoge 3dprintingofpharmaceuticalapplicationdrugscreeninganddrugdelivery
AT ahnminjun 3dprintingofpharmaceuticalapplicationdrugscreeninganddrugdelivery
AT chowonwoo 3dprintingofpharmaceuticalapplicationdrugscreeninganddrugdelivery
AT kimbyoungsoo 3dprintingofpharmaceuticalapplicationdrugscreeninganddrugdelivery
AT chodongwoo 3dprintingofpharmaceuticalapplicationdrugscreeninganddrugdelivery