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Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism

Cold atmospheric plasma (CAP) is a near-room-temperature, partially ionized gas composed of reactive neutral and charged species. CAP also generates physical factors, including ultraviolet (UV) radiation and thermal and electromagnetic (EM) effects. Studies over the past decade demonstrated that CAP...

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Autores principales: Yan, Dayun, Malyavko, Alisa, Wang, Qihui, Ostrikov, Kostya (Ken), Sherman, Jonathan H., Keidar, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465976/
https://www.ncbi.nlm.nih.gov/pubmed/34572443
http://dx.doi.org/10.3390/biomedicines9091259
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author Yan, Dayun
Malyavko, Alisa
Wang, Qihui
Ostrikov, Kostya (Ken)
Sherman, Jonathan H.
Keidar, Michael
author_facet Yan, Dayun
Malyavko, Alisa
Wang, Qihui
Ostrikov, Kostya (Ken)
Sherman, Jonathan H.
Keidar, Michael
author_sort Yan, Dayun
collection PubMed
description Cold atmospheric plasma (CAP) is a near-room-temperature, partially ionized gas composed of reactive neutral and charged species. CAP also generates physical factors, including ultraviolet (UV) radiation and thermal and electromagnetic (EM) effects. Studies over the past decade demonstrated that CAP could effectively induce death in a wide range of cell types, from mammalian to bacterial cells. Viruses can also be inactivated by a CAP treatment. The CAP-triggered cell-death types mainly include apoptosis, necrosis, and autophagy-associated cell death. Cell death and virus inactivation triggered by CAP are the foundation of the emerging medical applications of CAP, including cancer therapy, sterilization, and wound healing. Here, we systematically analyze the entire picture of multi-modal biological destruction by CAP treatment and their underlying mechanisms based on the latest discoveries particularly the physical effects on cancer cells.
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spelling pubmed-84659762021-09-27 Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism Yan, Dayun Malyavko, Alisa Wang, Qihui Ostrikov, Kostya (Ken) Sherman, Jonathan H. Keidar, Michael Biomedicines Review Cold atmospheric plasma (CAP) is a near-room-temperature, partially ionized gas composed of reactive neutral and charged species. CAP also generates physical factors, including ultraviolet (UV) radiation and thermal and electromagnetic (EM) effects. Studies over the past decade demonstrated that CAP could effectively induce death in a wide range of cell types, from mammalian to bacterial cells. Viruses can also be inactivated by a CAP treatment. The CAP-triggered cell-death types mainly include apoptosis, necrosis, and autophagy-associated cell death. Cell death and virus inactivation triggered by CAP are the foundation of the emerging medical applications of CAP, including cancer therapy, sterilization, and wound healing. Here, we systematically analyze the entire picture of multi-modal biological destruction by CAP treatment and their underlying mechanisms based on the latest discoveries particularly the physical effects on cancer cells. MDPI 2021-09-18 /pmc/articles/PMC8465976/ /pubmed/34572443 http://dx.doi.org/10.3390/biomedicines9091259 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Dayun
Malyavko, Alisa
Wang, Qihui
Ostrikov, Kostya (Ken)
Sherman, Jonathan H.
Keidar, Michael
Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title_full Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title_fullStr Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title_full_unstemmed Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title_short Multi-Modal Biological Destruction by Cold Atmospheric Plasma: Capability and Mechanism
title_sort multi-modal biological destruction by cold atmospheric plasma: capability and mechanism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465976/
https://www.ncbi.nlm.nih.gov/pubmed/34572443
http://dx.doi.org/10.3390/biomedicines9091259
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