The Development of Ru(II)-Based Photoactivated Chemotherapy Agents

Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn increasing attention due to its high selectivity and low side effects by spatio-temporal control of irradiation. Compared with photodynamic therapy (PDT), oxygen-independent PACT is more suitable for treating hypoxi...

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Detalles Bibliográficos
Autores principales: Chen, Yongjie, Bai, Lijuan, Zhang, Pu, Zhao, Hua, Zhou, Qianxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465985/
https://www.ncbi.nlm.nih.gov/pubmed/34577150
http://dx.doi.org/10.3390/molecules26185679
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author Chen, Yongjie
Bai, Lijuan
Zhang, Pu
Zhao, Hua
Zhou, Qianxiong
author_facet Chen, Yongjie
Bai, Lijuan
Zhang, Pu
Zhao, Hua
Zhou, Qianxiong
author_sort Chen, Yongjie
collection PubMed
description Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn increasing attention due to its high selectivity and low side effects by spatio-temporal control of irradiation. Compared with photodynamic therapy (PDT), oxygen-independent PACT is more suitable for treating hypoxic tumors. By finely tuning ligand structures and coordination configurations, many Ru(II) complexes can undergo photoinduced ligand dissociation, and the resulting Ru(II) aqua species and/or free ligands may have anticancer activity, showing their potential as PACT agents. In this mini-review, we summarized the progress in Ru(II)-based PACT agents, as well as challenges that researchers in this field still face.
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spelling pubmed-84659852021-09-27 The Development of Ru(II)-Based Photoactivated Chemotherapy Agents Chen, Yongjie Bai, Lijuan Zhang, Pu Zhao, Hua Zhou, Qianxiong Molecules Review Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn increasing attention due to its high selectivity and low side effects by spatio-temporal control of irradiation. Compared with photodynamic therapy (PDT), oxygen-independent PACT is more suitable for treating hypoxic tumors. By finely tuning ligand structures and coordination configurations, many Ru(II) complexes can undergo photoinduced ligand dissociation, and the resulting Ru(II) aqua species and/or free ligands may have anticancer activity, showing their potential as PACT agents. In this mini-review, we summarized the progress in Ru(II)-based PACT agents, as well as challenges that researchers in this field still face. MDPI 2021-09-18 /pmc/articles/PMC8465985/ /pubmed/34577150 http://dx.doi.org/10.3390/molecules26185679 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Yongjie
Bai, Lijuan
Zhang, Pu
Zhao, Hua
Zhou, Qianxiong
The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title_full The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title_fullStr The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title_full_unstemmed The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title_short The Development of Ru(II)-Based Photoactivated Chemotherapy Agents
title_sort development of ru(ii)-based photoactivated chemotherapy agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465985/
https://www.ncbi.nlm.nih.gov/pubmed/34577150
http://dx.doi.org/10.3390/molecules26185679
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