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Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering

Background and Objectives: Despite the association between hyperchloremia and adverse outcomes, mortality risks among patients with hyperchloremia have not consistently been observed among all studies with different patient populations with hyperchloremia. The objective of this study was to characte...

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Autores principales: Thongprayoon, Charat, Nissaisorakarn, Voravech, Pattharanitima, Pattharawin, Mao, Michael A., Kattah, Andrea G., Keddis, Mira T., Dumancas, Carissa Y., Vallabhajosyula, Saraschandra, Petnak, Tananchai, Erickson, Stephen B., Dillon, John J., Garovic, Vesna D., Kashani, Kianoush B., Cheungpasitporn, Wisit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465989/
https://www.ncbi.nlm.nih.gov/pubmed/34577826
http://dx.doi.org/10.3390/medicina57090903
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author Thongprayoon, Charat
Nissaisorakarn, Voravech
Pattharanitima, Pattharawin
Mao, Michael A.
Kattah, Andrea G.
Keddis, Mira T.
Dumancas, Carissa Y.
Vallabhajosyula, Saraschandra
Petnak, Tananchai
Erickson, Stephen B.
Dillon, John J.
Garovic, Vesna D.
Kashani, Kianoush B.
Cheungpasitporn, Wisit
author_facet Thongprayoon, Charat
Nissaisorakarn, Voravech
Pattharanitima, Pattharawin
Mao, Michael A.
Kattah, Andrea G.
Keddis, Mira T.
Dumancas, Carissa Y.
Vallabhajosyula, Saraschandra
Petnak, Tananchai
Erickson, Stephen B.
Dillon, John J.
Garovic, Vesna D.
Kashani, Kianoush B.
Cheungpasitporn, Wisit
author_sort Thongprayoon, Charat
collection PubMed
description Background and Objectives: Despite the association between hyperchloremia and adverse outcomes, mortality risks among patients with hyperchloremia have not consistently been observed among all studies with different patient populations with hyperchloremia. The objective of this study was to characterize hyperchloremic patients at hospital admission into clusters using an unsupervised machine learning approach and to evaluate the mortality risk among these distinct clusters. Materials and Methods: We performed consensus cluster analysis based on demographic information, principal diagnoses, comorbidities, and laboratory data among 11,394 hospitalized adult patients with admission serum chloride of >108 mEq/L. We calculated the standardized mean difference of each variable to identify each cluster’s key features. We assessed the association of each hyperchloremia cluster with hospital and one-year mortality. Results: There were three distinct clusters of patients with admission hyperchloremia: 3237 (28%), 4059 (36%), and 4098 (36%) patients in clusters 1 through 3, respectively. Cluster 1 was characterized by higher serum chloride but lower serum sodium, bicarbonate, hemoglobin, and albumin. Cluster 2 was characterized by younger age, lower comorbidity score, lower serum chloride, and higher estimated glomerular filtration (eGFR), hemoglobin, and albumin. Cluster 3 was characterized by older age, higher comorbidity score, higher serum sodium, potassium, and lower eGFR. Compared with cluster 2, odds ratios for hospital mortality were 3.60 (95% CI 2.33–5.56) for cluster 1, and 4.83 (95% CI 3.21–7.28) for cluster 3, whereas hazard ratios for one-year mortality were 4.49 (95% CI 3.53–5.70) for cluster 1 and 6.96 (95% CI 5.56–8.72) for cluster 3. Conclusions: Our cluster analysis identified three clinically distinct phenotypes with differing mortality risks in hospitalized patients with admission hyperchloremia.
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spelling pubmed-84659892021-09-27 Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering Thongprayoon, Charat Nissaisorakarn, Voravech Pattharanitima, Pattharawin Mao, Michael A. Kattah, Andrea G. Keddis, Mira T. Dumancas, Carissa Y. Vallabhajosyula, Saraschandra Petnak, Tananchai Erickson, Stephen B. Dillon, John J. Garovic, Vesna D. Kashani, Kianoush B. Cheungpasitporn, Wisit Medicina (Kaunas) Article Background and Objectives: Despite the association between hyperchloremia and adverse outcomes, mortality risks among patients with hyperchloremia have not consistently been observed among all studies with different patient populations with hyperchloremia. The objective of this study was to characterize hyperchloremic patients at hospital admission into clusters using an unsupervised machine learning approach and to evaluate the mortality risk among these distinct clusters. Materials and Methods: We performed consensus cluster analysis based on demographic information, principal diagnoses, comorbidities, and laboratory data among 11,394 hospitalized adult patients with admission serum chloride of >108 mEq/L. We calculated the standardized mean difference of each variable to identify each cluster’s key features. We assessed the association of each hyperchloremia cluster with hospital and one-year mortality. Results: There were three distinct clusters of patients with admission hyperchloremia: 3237 (28%), 4059 (36%), and 4098 (36%) patients in clusters 1 through 3, respectively. Cluster 1 was characterized by higher serum chloride but lower serum sodium, bicarbonate, hemoglobin, and albumin. Cluster 2 was characterized by younger age, lower comorbidity score, lower serum chloride, and higher estimated glomerular filtration (eGFR), hemoglobin, and albumin. Cluster 3 was characterized by older age, higher comorbidity score, higher serum sodium, potassium, and lower eGFR. Compared with cluster 2, odds ratios for hospital mortality were 3.60 (95% CI 2.33–5.56) for cluster 1, and 4.83 (95% CI 3.21–7.28) for cluster 3, whereas hazard ratios for one-year mortality were 4.49 (95% CI 3.53–5.70) for cluster 1 and 6.96 (95% CI 5.56–8.72) for cluster 3. Conclusions: Our cluster analysis identified three clinically distinct phenotypes with differing mortality risks in hospitalized patients with admission hyperchloremia. MDPI 2021-08-30 /pmc/articles/PMC8465989/ /pubmed/34577826 http://dx.doi.org/10.3390/medicina57090903 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Thongprayoon, Charat
Nissaisorakarn, Voravech
Pattharanitima, Pattharawin
Mao, Michael A.
Kattah, Andrea G.
Keddis, Mira T.
Dumancas, Carissa Y.
Vallabhajosyula, Saraschandra
Petnak, Tananchai
Erickson, Stephen B.
Dillon, John J.
Garovic, Vesna D.
Kashani, Kianoush B.
Cheungpasitporn, Wisit
Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title_full Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title_fullStr Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title_full_unstemmed Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title_short Subtyping Hyperchloremia among Hospitalized Patients by Machine Learning Consensus Clustering
title_sort subtyping hyperchloremia among hospitalized patients by machine learning consensus clustering
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465989/
https://www.ncbi.nlm.nih.gov/pubmed/34577826
http://dx.doi.org/10.3390/medicina57090903
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