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It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition

The body composition of patients with celiac disease (CD), on which the effects of a gluten-free diet (GFD) are controversial, differs from that of the average population. In this study, we aimed to compare the body composition across CD patients before a GFD, CD patients after a one-year GFD and no...

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Autores principales: Vereczkei, Zsófia, Farkas, Nelli, Hegyi, Péter, Imrei, Marcell, Földi, Mária, Szakács, Zsolt, Kiss, Szabolcs, Solymár, Margit, Nagy, Rita, Bajor, Judit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466091/
https://www.ncbi.nlm.nih.gov/pubmed/34578835
http://dx.doi.org/10.3390/nu13092947
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author Vereczkei, Zsófia
Farkas, Nelli
Hegyi, Péter
Imrei, Marcell
Földi, Mária
Szakács, Zsolt
Kiss, Szabolcs
Solymár, Margit
Nagy, Rita
Bajor, Judit
author_facet Vereczkei, Zsófia
Farkas, Nelli
Hegyi, Péter
Imrei, Marcell
Földi, Mária
Szakács, Zsolt
Kiss, Szabolcs
Solymár, Margit
Nagy, Rita
Bajor, Judit
author_sort Vereczkei, Zsófia
collection PubMed
description The body composition of patients with celiac disease (CD), on which the effects of a gluten-free diet (GFD) are controversial, differs from that of the average population. In this study, we aimed to compare the body composition across CD patients before a GFD, CD patients after a one-year GFD and non-celiac control subjects. A systematic search was conducted using five electronic databases up to 15 July 2021 for studies that reported at least one of the pre-specified outcomes. In meta-analyses, weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. A total of 25 studies were eligible for systematic review, seven of which were included in meta-analysis. During a ≥1-year GFD, fat mass of CD patients, compared to that at baseline, significantly increased (WMD = 4.1 kg, 95% CI = 1.5 to 6.6, three studies). In CD patients after a ≥1-year GFD, compared to non-celiac controls, fat mass (WMD = −5.8 kg, 95% CI = −8.7 to −2.9, three studies) and fat-free mass (WMD = −1.9 kg, 95% CI = −3.0 to −0.7, three studies) were significantly lower. In conclusion, body composition-related parameters of CD patients differ from that of the non-celiac control subjects even after a longstanding GFD.
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spelling pubmed-84660912021-09-27 It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition Vereczkei, Zsófia Farkas, Nelli Hegyi, Péter Imrei, Marcell Földi, Mária Szakács, Zsolt Kiss, Szabolcs Solymár, Margit Nagy, Rita Bajor, Judit Nutrients Review The body composition of patients with celiac disease (CD), on which the effects of a gluten-free diet (GFD) are controversial, differs from that of the average population. In this study, we aimed to compare the body composition across CD patients before a GFD, CD patients after a one-year GFD and non-celiac control subjects. A systematic search was conducted using five electronic databases up to 15 July 2021 for studies that reported at least one of the pre-specified outcomes. In meta-analyses, weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. A total of 25 studies were eligible for systematic review, seven of which were included in meta-analysis. During a ≥1-year GFD, fat mass of CD patients, compared to that at baseline, significantly increased (WMD = 4.1 kg, 95% CI = 1.5 to 6.6, three studies). In CD patients after a ≥1-year GFD, compared to non-celiac controls, fat mass (WMD = −5.8 kg, 95% CI = −8.7 to −2.9, three studies) and fat-free mass (WMD = −1.9 kg, 95% CI = −3.0 to −0.7, three studies) were significantly lower. In conclusion, body composition-related parameters of CD patients differ from that of the non-celiac control subjects even after a longstanding GFD. MDPI 2021-08-25 /pmc/articles/PMC8466091/ /pubmed/34578835 http://dx.doi.org/10.3390/nu13092947 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vereczkei, Zsófia
Farkas, Nelli
Hegyi, Péter
Imrei, Marcell
Földi, Mária
Szakács, Zsolt
Kiss, Szabolcs
Solymár, Margit
Nagy, Rita
Bajor, Judit
It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title_full It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title_fullStr It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title_full_unstemmed It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title_short It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
title_sort it is high time for personalized dietary counseling in celiac disease: a systematic review and meta-analysis on body composition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466091/
https://www.ncbi.nlm.nih.gov/pubmed/34578835
http://dx.doi.org/10.3390/nu13092947
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