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A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy

One of the goals of modern dynamic radiotherapy treatments is to deliver high-dose values in the shortest irradiation time possible. In such a context, fast X-ray detectors and reliable front-end readout electronics for beam diagnostics are crucial to meet the necessary quality assurance requirement...

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Autores principales: Pettinato, Sara, Girolami, Marco, Olivieri, Riccardo, Stravato, Antonella, Caruso, Cristina, Salvatori, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466252/
https://www.ncbi.nlm.nih.gov/pubmed/34576426
http://dx.doi.org/10.3390/ma14185203
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author Pettinato, Sara
Girolami, Marco
Olivieri, Riccardo
Stravato, Antonella
Caruso, Cristina
Salvatori, Stefano
author_facet Pettinato, Sara
Girolami, Marco
Olivieri, Riccardo
Stravato, Antonella
Caruso, Cristina
Salvatori, Stefano
author_sort Pettinato, Sara
collection PubMed
description One of the goals of modern dynamic radiotherapy treatments is to deliver high-dose values in the shortest irradiation time possible. In such a context, fast X-ray detectors and reliable front-end readout electronics for beam diagnostics are crucial to meet the necessary quality assurance requirements of care plans. This work describes a diamond-based detection system able to acquire and process the dose delivered by every single pulse sourced by a linear accelerator (LINAC) generating 6-MV X-ray beams. The proposed system is able to measure the intensity of X-ray pulses in a limited integration period around each pulse, thus reducing the inaccuracy induced by unnecessarily long acquisition times. Detector sensitivity under 6-MV X-photons in the 0.1–10 Gy dose range was measured to be 302.2 nC/Gy at a bias voltage of 10 V. Pulse-by-pulse measurements returned a charge-per-pulse value of 84.68 pC, in excellent agreement with the value estimated (but not directly measured) with a commercial electrometer operating in a continuous integration mode. Significantly, by intrinsically holding the acquired signal, the proposed system enables signal processing even in the millisecond period between two consecutive pulses, thus allowing for effective real-time dose-per-pulse monitoring.
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spelling pubmed-84662522021-09-27 A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy Pettinato, Sara Girolami, Marco Olivieri, Riccardo Stravato, Antonella Caruso, Cristina Salvatori, Stefano Materials (Basel) Article One of the goals of modern dynamic radiotherapy treatments is to deliver high-dose values in the shortest irradiation time possible. In such a context, fast X-ray detectors and reliable front-end readout electronics for beam diagnostics are crucial to meet the necessary quality assurance requirements of care plans. This work describes a diamond-based detection system able to acquire and process the dose delivered by every single pulse sourced by a linear accelerator (LINAC) generating 6-MV X-ray beams. The proposed system is able to measure the intensity of X-ray pulses in a limited integration period around each pulse, thus reducing the inaccuracy induced by unnecessarily long acquisition times. Detector sensitivity under 6-MV X-photons in the 0.1–10 Gy dose range was measured to be 302.2 nC/Gy at a bias voltage of 10 V. Pulse-by-pulse measurements returned a charge-per-pulse value of 84.68 pC, in excellent agreement with the value estimated (but not directly measured) with a commercial electrometer operating in a continuous integration mode. Significantly, by intrinsically holding the acquired signal, the proposed system enables signal processing even in the millisecond period between two consecutive pulses, thus allowing for effective real-time dose-per-pulse monitoring. MDPI 2021-09-10 /pmc/articles/PMC8466252/ /pubmed/34576426 http://dx.doi.org/10.3390/ma14185203 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pettinato, Sara
Girolami, Marco
Olivieri, Riccardo
Stravato, Antonella
Caruso, Cristina
Salvatori, Stefano
A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title_full A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title_fullStr A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title_full_unstemmed A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title_short A Diamond-Based Dose-per-Pulse X-ray Detector for Radiation Therapy
title_sort diamond-based dose-per-pulse x-ray detector for radiation therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466252/
https://www.ncbi.nlm.nih.gov/pubmed/34576426
http://dx.doi.org/10.3390/ma14185203
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