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Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for deca...

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Detalles Bibliográficos
Autores principales: Du, Wei, Gao, Yiru, Liu, Li, Sai, Sixiang, Ding, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466259/
https://www.ncbi.nlm.nih.gov/pubmed/34576268
http://dx.doi.org/10.3390/ijms221810104
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author Du, Wei
Gao, Yiru
Liu, Li
Sai, Sixiang
Ding, Chen
author_facet Du, Wei
Gao, Yiru
Liu, Li
Sai, Sixiang
Ding, Chen
author_sort Du, Wei
collection PubMed
description Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.
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spelling pubmed-84662592021-09-27 Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies Du, Wei Gao, Yiru Liu, Li Sai, Sixiang Ding, Chen Int J Mol Sci Review Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies. MDPI 2021-09-18 /pmc/articles/PMC8466259/ /pubmed/34576268 http://dx.doi.org/10.3390/ijms221810104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Du, Wei
Gao, Yiru
Liu, Li
Sai, Sixiang
Ding, Chen
Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title_full Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title_fullStr Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title_full_unstemmed Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title_short Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
title_sort striking back against fungal infections: the utilization of nanosystems for antifungal strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466259/
https://www.ncbi.nlm.nih.gov/pubmed/34576268
http://dx.doi.org/10.3390/ijms221810104
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