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Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies
Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for deca...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466259/ https://www.ncbi.nlm.nih.gov/pubmed/34576268 http://dx.doi.org/10.3390/ijms221810104 |
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author | Du, Wei Gao, Yiru Liu, Li Sai, Sixiang Ding, Chen |
author_facet | Du, Wei Gao, Yiru Liu, Li Sai, Sixiang Ding, Chen |
author_sort | Du, Wei |
collection | PubMed |
description | Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies. |
format | Online Article Text |
id | pubmed-8466259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-84662592021-09-27 Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies Du, Wei Gao, Yiru Liu, Li Sai, Sixiang Ding, Chen Int J Mol Sci Review Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies. MDPI 2021-09-18 /pmc/articles/PMC8466259/ /pubmed/34576268 http://dx.doi.org/10.3390/ijms221810104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Du, Wei Gao, Yiru Liu, Li Sai, Sixiang Ding, Chen Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title_full | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title_fullStr | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title_full_unstemmed | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title_short | Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies |
title_sort | striking back against fungal infections: the utilization of nanosystems for antifungal strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466259/ https://www.ncbi.nlm.nih.gov/pubmed/34576268 http://dx.doi.org/10.3390/ijms221810104 |
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